Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | UBE2M | P61081 | 2/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2560391 | 0.91 | ALOX5 (0.47) | ALOX5RAB9AMAPTTSHRGAA | |
| SCHEMBL2565684 | 0.85 | ALOX5 (0.49) | ALOX5RAB9AMAPTTSHRALDH1A1 | |
| SCHEMBL2563257 | 0.85 | ALOX5 (0.39) | ALOX5RAB9AMAPTTSHRGAA | |
| SCHEMBL2565922 | 0.84 | ALOX5 (0.44) | ALOX5RAB9AMAPTTSHRGAA | |
| SCHEMBL2560911 | 0.84 | ALOX5 (0.44) | ALOX5RAB9AMAPTGAAMAPK1 | |
| SCHEMBL2551908 | 0.82 | ALOX5 (0.46) | ALOX5RAB9AMAPTTSHRGAA | |
| SCHEMBL2564779 | 0.82 | ALOX5 (0.46) | ALOX5RAB9AMAPTGAAMAPK1 | |
| SCHEMBL2569287 | 0.81 | ALOX5 (0.44) | ALOX5RAB9AMAPTMAPK1ALDH1A1 | |
| SCHEMBL2554490 | 0.79 | ALOX5 (0.50) | ALOX5RAB9AMAPTTSHRGAA | |
| SCHEMBL2565339 | 0.78 | ALOX5 (0.53) | ALOX5RAB9AMAPTTSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011121223-A1 | 6-(ALKYL- OR CYCLOALKYL-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLE DERIVATIVES: PREPARATION, APPLICATION AS MEDICAMENTS AND USE AS MET INHIBITORS | SANOFI-AVENTIS (FR) | 2011-10-06 | — | — | WO | disclosed |