Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 3/20 | 0.59 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.59 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15341777 | 0.81 | CRBN (0.59) | CRBNDDB1TDP1NOTUMPKM | |
| SCHEMBL1380327 | 0.79 | CRBN (0.66) | CRBNDDB1LMNAPKMALDH1A1 | |
| SCHEMBL5325743 | 0.79 | CRBN (0.66) | CRBNDDB1MGLLPKMKDM4E | |
| SCHEMBL8721189 | 0.79 | MGLL (0.46) | CRBNDDB1MGLLTDP1KMT2A | |
| SCHEMBL18640431 | 0.77 | CRBN (0.53) | CRBNDDB1LMNAPOLBPKM | |
| SCHEMBL23120610 | 0.76 | CRBN (0.66) | CRBNDDB1MGLLKMT2ALMNA | |
| SCHEMBL21995599 | 0.76 | CRBN (0.66) | CRBNDDB1MGLLKMT2APOLB | |
| SCHEMBL25207533 | 0.76 | CRBN (0.66) | CRBNDDB1MGLLTDP1KMT2A | |
| SCHEMBL28744560 | 0.75 | CRBN (0.59) | CRBNDDB1MGLLKMT2AMEN1 | |
| SCHEMBL23345977 | 0.75 | CRBN (0.59) | CRBNDDB1KMT2AMEN1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023096995-A1 | COMPOSITIONS AND METHODS COMPRISING SUBSTITUTED N-(2-CHLORO-6-METHYLPHENYL)-2-((6-(6-MEMBERED HETEROCYCLOALKYL)-2-METHYLPYRIMIDIN-4-YL)AMINO)THIAZOLE-5-CARBOXAMIDE ANALOGUES | ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. (US) | 2023-06-01 | — | — | WO | disclosed |