Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2560735 | 0.80 | GRM5 (0.40) | GRM5 | |
| SCHEMBL2559283 | 0.74 | GRM5 (0.32) | GRM5 | |
| SCHEMBL2515085 | 0.72 | GRM5 (0.51) | GRM5 | |
| SCHEMBL2560942 | 0.68 | KDM4E (0.37) | GRM5 | |
| SCHEMBL14844014 | 0.68 | GRM5 (0.34) | GRM5 | |
| SCHEMBL19402043 | 0.68 | RPS6KA5 (0.35) | GRM5 | |
| SCHEMBL2517074 | 0.68 | GRM5 (0.56) | GRM5 | |
| SCHEMBL2563575 | 0.67 | — | — | |
| SCHEMBL2556087 | 0.66 | BPTF (0.41) | — | |
| SCHEMBL14843988 | 0.65 | CHRNB2 (0.43) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558457-A1 | ARYLETHYNYL DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2013-02-20 | — | — | EP | disclosed |
| WO-2011128279-A1 | ARYLETHYNYL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-10-20 | — | — | WO | disclosed |