SCHEMBL25566705

SCHEMBL25566705

Cn1nc(N2CCC(=O)NC2=O)c2ccc(C(C)(C)C)nc21

nearest known ligand 0.57

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 17/20 0.57
DDB1 Q16531 16/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25595608 0.85 CRBN (0.60) CRBNDDB1
SCHEMBL25566822 0.77 CRBN (0.72) CRBNDDB1
SCHEMBL23551579 0.75 CRBN (0.77) CRBNDDB1
SCHEMBL25566821 0.75 CRBN (0.72) CRBNDDB1
SCHEMBL25667304 0.74 CRBN (0.52) CRBNDDB1
SCHEMBL30258522 0.73 CRBN (1.00) CRBNDDB1
SCHEMBL26826457 0.73 CRBN (1.00) CRBNDDB1
SCHEMBL30472890 0.72 CRBN (1.00) CRBNDDB1
SCHEMBL28984072 0.72 CRBN (1.00) CRBNDDB1
SCHEMBL25023330 0.72 CRBN (0.70) CRBNDDB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023083194-A1 WEE1 PROTEIN KINASE DEGRADATION AGENT AND USE THEREOF 杭州格博生物医药有限公司 2023-05-19 WO disclosed