Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.49 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.49 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 4/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.34 |
| ▸ | KDR | P35968 | 4/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21916084 | 0.79 | BRD4 (0.55) | BRD4BRPF1CREBBPEP300KMT2A | |
| SCHEMBL11307800 | 0.78 | CYP1A2 (0.57) | BRD4BRPF1CREBBPALDH1A1RAB9A | |
| SCHEMBL394139 | 0.78 | ALDH1A1 (0.46) | ALDH1A1RAB9APOLBKMT2AGAA | |
| SCHEMBL15331397 | 0.77 | ALDH1A1 (0.58) | ALDH1A1RAB9APOLBKMT2AGAA | |
| SCHEMBL25313189 | 0.76 | GRK5 (0.43) | ALDH1A1RAB9APOLBKMT2ANPSR1 | |
| SCHEMBL25312496 | 0.76 | GRK5 (0.43) | ALDH1A1RAB9ATSHRCYP1A2PRKAA2 | |
| SCHEMBL18656646 | 0.76 | ALDH1A1 (0.39) | BRD4BRPF1CREBBPALDH1A1RAB9A | |
| SCHEMBL13303521 | 0.76 | ALDH1A1 (0.39) | BRD4BRPF1CREBBPALDH1A1RAB9A | |
| SCHEMBL6832974 | 0.75 | KDR (0.53) | POLBKMT2ANPSR1TSHRCSF1R | |
| SCHEMBL25313535 | 0.74 | GRK5 (0.45) | NPSR1TSHRCSF1RPRKAA2PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023078207-A1 | 6-POSITION-SUBSTITUTED INDOLINONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF | 南京中医药大学 | 2023-05-11 | — | — | WO | disclosed |
| CN-114213396-B | Indole-2-ketone compound and preparation method and application thereof | 深圳市乐土生物医药有限公司 | 2023-03-24 | — | — | CN | disclosed |
| CN-114213396-A | Indole-2-ketone compound and preparation method and application thereof | 深圳市乐土生物医药有限公司 | 2022-03-22 | — | — | CN | disclosed |