SCHEMBL25566853

SCHEMBL25566853

N#Cc1ccc2c(c1)C1c3ccccc3C2c2ccc(C#N)cc21

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA1 P02708 1/20 0.46
CHRNG P07510 1/20 0.46
CHRNB1 P11230 1/20 0.46
CHRNB2 P17787 1/20 0.46
CHRNB4 P30926 1/20 0.46
CHRNA3 P32297 1/20 0.46
CHRNA4 P43681 1/20 0.46
CHRND Q07001 1/20 0.46
TSHR P16473 1/20 0.42
ALDH1A1 P00352 2/20 0.41
KDM4E B2RXH2 1/20 0.41
GAA P10253 1/20 0.41
CA1 P00915 2/20 0.40
CA2 P00918 2/20 0.40
LOXL2 Q9Y4K0 1/20 0.40
ENPP2 Q13822 1/20 0.39
NOS3 P29474 1/20 0.39
NOS1 P29475 1/20 0.39
NOS2 P35228 1/20 0.39
GRIN2D O15399 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19207348 0.93 CHRNA1 (0.50) CHRNA1CHRNGCHRNB1CHRNB2CHRNB4
SCHEMBL24791025 0.93 CHRNA1 (0.50) CHRNA1CHRNGCHRNB1CHRNB2CHRNB4
SCHEMBL25566977 0.85 CHRNA1 (0.36) CHRNA1CHRNGCHRNB1CHRNB2CHRNB4
SCHEMBL25567820 0.80 STS (0.39) GRIN2BMAOAMAOBADRA2CADORA2A
SCHEMBL25565424 0.79 MEN1 (0.47) TSHRALDH1A1KDM4ECLK4MAPT
SCHEMBL13037664 0.77 CHRNA1 (0.39) CHRNA1CHRNGCHRNB1CHRNB2CHRNB4
SCHEMBL25566982 0.77 CHRNA1 (0.39) CHRNA1CHRNGCHRNB1CHRNB2CHRNB4
SCHEMBL25567063 0.77 CHRNA1 (0.39) CHRNA1CHRNGCHRNB1CHRNB2CHRNB4
SCHEMBL10842361 0.72 HTR2A (0.38) CHRNA1CHRNGCHRNB1CHRNB2CHRNB4
SCHEMBL18561415 0.72 DRD2 (0.39) CHRNA1CHRNGCHRNB1CHRNB2CHRNB4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023094412-A1 MATERIALS FOR ELECTRONIC DEVICES MERCK PATENT GMBH (DE) 2023-06-01 WO disclosed