Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 2/20 | 0.39 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | GNRHR | P30968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL14633797 | 0.99 | KMT2A (0.44) | KMT2ABLMMEN1NPC1CCR3 | |
| Hydrochloric Acid SCHEMBL2554729 | 0.95 | KMT2A (0.42) | KMT2ABLMMEN1NPC1CCR3 | |
| SCHEMBL2554628 | 0.89 | HTR2A (0.41) | CCR3GRM2HTR2A | |
| SCHEMBL2551227 | 0.87 | SLC6A2 (0.47) | KMT2AMEN1CCR3 | |
| Hydrochloric Acid SCHEMBL14633798 | 0.86 | SLC6A2 (0.46) | KMT2AMEN1CCR3 | |
| Hydrochloric Acid SCHEMBL2553261 | 0.83 | SLC6A2 (0.46) | KMT2AMEN1CCR3 | |
| SCHEMBL16390898 | 0.79 | SLC6A2 (0.46) | KMT2AMEN1CCR3 | |
| SCHEMBL2555053 | 0.76 | SSTR5 (0.42) | HTR2A | |
| Hydrochloric Acid SCHEMBL14633467 | 0.75 | KCNH2 (0.42) | — | |
| SCHEMBL2553797 | 0.75 | CCR3 (0.47) | CCR3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2556074-A1 | TRICYCLIC INDAZOLE COMPOUND, METHOD OF PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING IT | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO - A.C.R.A.F. - S.p.A. (IT) | 2013-02-13 | — | — | EP | disclosed |
| WO-2011124430-A1 | TRICYCLIC INDAZOLE COMPOUND, METHOD OF PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING IT | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2011-10-13 | — | — | WO | disclosed |