Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2576250 | 0.88 | PDE10A (0.46) | PDE10APDE4BTP53POLBCYP19A1 | |
| SCHEMBL2560840 | 0.88 | PDE10A (0.46) | PDE10APDE4BTP53POLB | |
| SCHEMBL8272011 | 0.86 | PDE10A (0.62) | PDE10APDE4BTP53POLBALDH1A1 | |
| SCHEMBL2560140 | 0.85 | PDE10A (0.47) | PDE10APDE4BTP53POLBCYP19A1 | |
| SCHEMBL2560888 | 0.81 | PDE10A (0.48) | PDE10APDE4BCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL2563017 | 0.79 | PDE10A (0.58) | PDE10APDE4BALDH1A1LMNA | |
| SCHEMBL7711267 | 0.79 | PDE10A (0.59) | PDE10APDE4BCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL2562898 | 0.79 | PDE10A (0.46) | PDE10APDE4BTP53POLBNPC1 | |
| SCHEMBL7709735 | 0.78 | PDE10A (0.52) | PDE10APDE4BALDH1A1CYP19A1CYP11B1 | |
| SCHEMBL2562618 | 0.78 | PDE10A (0.64) | PDE10APDE4BPOLBCYP19A1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | claimed |