Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.52 |
| ▸ | HCRTR1 | O43613 | 10/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 10/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7706978 | 0.92 | PDE10A (0.48) | PDE10AHCRTR1HCRTR2PDE4BCYP19A1 | |
| SCHEMBL7706977 | 0.92 | PDE10A (0.48) | PDE10AHCRTR1HCRTR2PDE4BALDH1A1 | |
| SCHEMBL2562618 | 0.80 | PDE10A (0.64) | PDE10APDE4BCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL7711267 | 0.80 | PDE10A (0.59) | PDE10APDE4BCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL7703764 | 0.79 | PDE10A (0.63) | PDE10APDE4BCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL7710971 | 0.79 | PDE10A (0.83) | PDE10APDE4BCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL2577995 | 0.78 | PDE10A (0.64) | PDE10APDE4BCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL2556919 | 0.78 | PDE10A (0.51) | PDE10APDE4BCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL7713587 | 0.78 | PDE10A (0.67) | PDE10APDE4BCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL2557003 | 0.78 | PDE10A (0.52) | PDE10AHCRTR1HCRTR2PDE4BCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |