Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 8/20 | 0.81 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29560611 | 0.89 | IGF1R (1.00) | IGF1RMEN1KMT2AGRIK1KDM4E | |
| SCHEMBL2563976 | 0.89 | IGF1R (1.00) | IGF1RMEN1KMT2AGRIK1KDM4E | |
| SCHEMBL31060203 | 0.89 | IGF1R (1.00) | IGF1RMEN1KMT2AGRIK1KDM4E | |
| SCHEMBL4302397 | 0.77 | IGF1R (0.79) | IGF1RMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL10221504 | 0.75 | MEN1 (0.67) | IGF1RMEN1KMT2AGRIK1KDM4E | |
| SCHEMBL6588509 | 0.75 | IGF1R (0.77) | IGF1RMEN1KMT2AGRIK1KDM4E | |
| SCHEMBL18500908 | 0.74 | ALDH1A1 (0.74) | MEN1KMT2AKDM4EALDH1A1NPSR1 | |
| SCHEMBL12316787 | 0.73 | KMT2A (0.82) | MEN1KMT2AGRIK1KDM4EALDH1A1 | |
| SCHEMBL1463298 | 0.73 | GRIK1 (1.00) | IGF1RMEN1KMT2AGRIK1KDM4E | |
| SCHEMBL4317042 | 0.73 | KMT2A (0.73) | MEN1KMT2AALDH1A1NPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10799473-B2 | Methods of inhibiting IGF-1R activation or downtream signalling thereof to reduce radiation-induced cellular senescence | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (US) | 2020-10-13 | — | — | US | claimed |
| US-20160000744-A1 | Methods of Inhibiting IGF-1R Activation or Downtream Signalling Thereof to Reduce Radiation-Induced Cellular Senescence | UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES | 2016-01-07 | — | — | US | claimed |
| WO-2014137946-A1 | METHODS OF INHIBITING IGF-1R ACTIVATION OR DOWNTREAM SIGNALLING THEREOF TO REDUCE RADIATION-INDUCED CELLULAR SENESCENCE | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (US) | 2014-09-12 | — | — | WO | claimed |
| WO-2011133668-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-10-27 | — | — | WO | claimed |
| US-11319376-B2 | Combination of glucagon receptor antagonists and PI3K pathway inhibitors for the treatment of cancer | REMD BIOTHERAPEUTICS, INC. (US) | 2022-05-03 | — | — | US | disclosed |
| US-10799473-B2 | Methods of inhibiting IGF-1R activation or downtream signalling thereof to reduce radiation-induced cellular senescence | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (US) | 2020-10-13 | — | — | US | disclosed |
| EP-3493847-A2 | COMBINATION OF GLUCAGON RECEPTOR ANTAGONISTS AND PI3K PATHWAY INHIBITORS FOR THE TREATMENT OF CANCER | REMD Biotherapeutics, Inc. (US) | 2019-06-12 | — | — | EP | disclosed |
| US-20190169300-A1 | COMBINATION OF GLUCAGON RECEPTOR ANTAGONISTS AND PI3K PATHWAY INHIBITORS FOR THE TREATMENT OF CANCER | REMD Biotherapeutics, Inc | 2019-06-06 | — | — | US | disclosed |
| WO-2018027084-A2 | COMBINATION OF GLUCAGON RECEPTOR ANTAGONISTS AND PI3K PATHWAY INHIBITORS FOR THE TREATMENT OF CANCER | REMD BIOTHERAPEUTICS, INC. (US) | 2018-02-08 | — | — | WO | disclosed |
| US-20160000744-A1 | Methods of Inhibiting IGF-1R Activation or Downtream Signalling Thereof to Reduce Radiation-Induced Cellular Senescence | UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES | 2016-01-07 | — | — | US | disclosed |
| WO-2014137946-A1 | METHODS OF INHIBITING IGF-1R ACTIVATION OR DOWNTREAM SIGNALLING THEREOF TO REDUCE RADIATION-INDUCED CELLULAR SENESCENCE | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (US) | 2014-09-12 | — | — | WO | disclosed |
| WO-2011133668-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-10-27 | — | — | WO | disclosed |