Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 9/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29560611 | 1.00 | IGF1R (1.00) | IGF1RMEN1KMT2AHTTGRIK1 | |
| SCHEMBL31060203 | 1.00 | IGF1R (1.00) | IGF1RMEN1KMT2AHTTGRIK1 | |
| SCHEMBL2556956 | 0.89 | IGF1R (0.81) | IGF1RMEN1KMT2AGRIK1KDM4E | |
| SCHEMBL4302397 | 0.88 | IGF1R (0.79) | IGF1RMEN1KMT2AHTTKDM4E | |
| SCHEMBL6588509 | 0.87 | IGF1R (0.77) | IGF1RMEN1KMT2AHTTGRIK1 | |
| SCHEMBL4855474 | 0.83 | HTT (0.75) | IGF1RMEN1KMT2AHTTKDM4E | |
| SCHEMBL6588862 | 0.82 | IGF1R (0.77) | IGF1RMEN1KMT2AHTTNPC1 | |
| SCHEMBL6588362 | 0.81 | IGF1R (0.71) | IGF1RMEN1KMT2AHTTKDM4E | |
| SCHEMBL6780760 | 0.80 | HTT (0.72) | IGF1RMEN1KMT2AHTTKDM4E | |
| SCHEMBL7690789 | 0.80 | IGF1R (0.67) | IGF1RMEN1KMT2AHTTGRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10799473-B2 | Methods of inhibiting IGF-1R activation or downtream signalling thereof to reduce radiation-induced cellular senescence | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (US) | 2020-10-13 | — | — | US | claimed |
| US-20160000744-A1 | Methods of Inhibiting IGF-1R Activation or Downtream Signalling Thereof to Reduce Radiation-Induced Cellular Senescence | UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES | 2016-01-07 | — | — | US | claimed |
| WO-2014137946-A1 | METHODS OF INHIBITING IGF-1R ACTIVATION OR DOWNTREAM SIGNALLING THEREOF TO REDUCE RADIATION-INDUCED CELLULAR SENESCENCE | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (US) | 2014-09-12 | — | — | WO | claimed |
| WO-2011133668-A2 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-10-27 | — | — | WO | claimed |
| EP-1150977-B1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2004-08-25 | — | — | EP | claimed |
| US-6699879-B1 | OBESITY, DIABETES, SLEEP DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-03-02 | — | — | US | claimed |
| US-6337338-B1 | INSULIN LIKE GROWTH FACTOR RECEPTOR IN MAMMALS | TELIK, INC. | 2002-01-08 | — | — | US | claimed |
| EP-1150977-A1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2001-11-07 | — | — | EP | claimed |
| WO-2000047577-A1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2000-08-17 | — | — | WO | claimed |
| WO-2000035455-A1 | HETEROARYL-ARYL UREAS AS IGF-1 RECEPTOR ANTAGONISTS | TELIK, INC. (US) | 2000-06-22 | — | — | WO | claimed |
| US-11319376-B2 | Combination of glucagon receptor antagonists and PI3K pathway inhibitors for the treatment of cancer | REMD BIOTHERAPEUTICS, INC. (US) | 2022-05-03 | — | — | US | disclosed |
| US-10799473-B2 | Methods of inhibiting IGF-1R activation or downtream signalling thereof to reduce radiation-induced cellular senescence | THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (US) | 2020-10-13 | — | — | US | disclosed |
| EP-3493847-A2 | COMBINATION OF GLUCAGON RECEPTOR ANTAGONISTS AND PI3K PATHWAY INHIBITORS FOR THE TREATMENT OF CANCER | REMD Biotherapeutics, Inc. (US) | 2019-06-12 | — | — | EP | disclosed |
| US-20190169300-A1 | COMBINATION OF GLUCAGON RECEPTOR ANTAGONISTS AND PI3K PATHWAY INHIBITORS FOR THE TREATMENT OF CANCER | REMD Biotherapeutics, Inc | 2019-06-06 | — | — | US | disclosed |
| US-20190160050-A1 | SMALL MOLECULE INHIBITION FOR PREVENTING OR TREATING FIBROTIC DISEASES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-05-30 | — | — | US | disclosed |
| US-6699879-B1 | OBESITY, DIABETES, SLEEP DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-03-02 | — | — | US | disclosed |
| US-6337338-B1 | INSULIN LIKE GROWTH FACTOR RECEPTOR IN MAMMALS | TELIK, INC. | 2002-01-08 | — | — | US | disclosed |
| EP-1150977-A1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000047577-A1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2000-08-17 | — | — | WO | disclosed |
| WO-2000035455-A1 | HETEROARYL-ARYL UREAS AS IGF-1 RECEPTOR ANTAGONISTS | TELIK, INC. (US) | 2000-06-22 | — | — | WO | disclosed |