Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | NT5E | P21589 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | TLR2 | O60603 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10220222 | 0.85 | BACE1 (0.53) | BACE1CYP2C19CYP3A4CYP2C9NT5E | |
| SCHEMBL264392 | 0.85 | BACE1 (0.46) | BACE1CYP2C19CYP3A4CYP2C9NT5E | |
| SCHEMBL2003231 | 0.81 | BACE1 (0.57) | BACE1CYP2C19CYP3A4CYP2C9NT5E | |
| SCHEMBL8005264 | 0.80 | CYP1A2 (0.55) | BACE1CYP2A6MAPTALDH1A1KDM4E | |
| SCHEMBL263494 | 0.79 | BACE1 (0.47) | BACE1CYP2C19CYP3A4CYP2C9NT5E | |
| SCHEMBL26167592 | 0.79 | HTR3A (0.43) | BACE1CYP2A6HDAC1HDAC2PPARA | |
| SCHEMBL2117037 | 0.78 | NT5E (0.57) | BACE1CYP2C19CYP3A4CYP2C9NT5E | |
| SCHEMBL1500481 | 0.75 | BACE1 (0.46) | BACE1CYP2C19CYP3A4CYP2C9CYP2A6 | |
| SCHEMBL30718863 | 0.75 | TYMS (0.34) | ALDH1A1CYP1A2 | |
| SCHEMBL27141565 | 0.75 | CYP2A6 (0.36) | CYP2A6MAPTALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4547658-A1 | WEE1 DEGRADING COMPOUNDS AND USES THEREOF | Bristol-Myers Squibb Company (US) | 2025-05-07 | — | — | EP | disclosed |
| CN-119325469-A | WEE1 degrading compounds and uses thereof | 百时美施贵宝公司 | 2025-01-17 | — | — | CN | disclosed |
| US-20240067632-A1 | WEE1 Degrading Compounds and Uses Thereof | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-02-29 | — | — | US | disclosed |
| WO-2024006881-A1 | WEE1 DEGRADING COMPOUNDS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-01-04 | — | — | WO | disclosed |
| US-20120316200-A1 | PYRIDONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-12-13 | — | — | US | disclosed |
| US-20120316200-A1 | PYRIDONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-12-13 | — | — | US | disclosed |
| US-20120316200-A1 | PYRIDONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-12-13 | — | — | US | disclosed |
| WO-2011130086-A1 | PYRIDONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-10-20 | — | — | WO | disclosed |
| WO-2011127643-A1 | PYRIDONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-10-20 | — | — | WO | disclosed |
| WO-2011127643-A1 | PYRIDONE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120316200-A1 | PYRIDONE DERIVATIVES | MC1R, MC5R, MCHR1 | BACE1 4566/4885CYP2C19 53/4885CYP3A4 207/4885 |
| US-20240067632-A1 | WEE1 Degrading Compounds and Uses Thereof | WEE1, WEE2, PPME1 | BACE1 2266/4885CYP2C19 4247/4885CYP3A4 3921/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.