Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CTSV | O60911 | 1/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.46 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3387313 | 0.89 | ALDH1A1 (0.55) | ALDH1A1TDP1CYP3A4ALOX15TP53 | |
| SCHEMBL28068351 | 0.88 | ALDH1A1 (0.62) | ALDH1A1TDP1CYP3A4ALOX15TP53 | |
| SCHEMBL1243828 | 0.87 | HTT (0.48) | ALDH1A1TDP1CYP3A4ALOX15TP53 | |
| SCHEMBL479085 | 0.87 | HTT (0.49) | ALDH1A1TDP1CYP3A4ALOX15TP53 | |
| SCHEMBL19754000 | 0.86 | MAPK1 (0.50) | ALDH1A1TDP1CYP3A4ALOX15TP53 | |
| SCHEMBL28428327 | 0.86 | ALDH1A1 (0.60) | ALDH1A1TDP1CYP3A4ALOX15TP53 | |
| SCHEMBL6589180 | 0.86 | HTT (0.63) | ALDH1A1TDP1CYP3A4ALOX15TP53 | |
| SCHEMBL27882095 | 0.86 | ALDH1A1 (0.60) | ALDH1A1TDP1CYP3A4ALOX15TP53 | |
| SCHEMBL3391556 | 0.86 | ALDH1A1 (0.53) | ALDH1A1TDP1CYP3A4ALOX15TP53 | |
| SCHEMBL8093106 | 0.85 | KMT2A (0.49) | ALDH1A1TDP1CYP3A4ALOX15TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4211116-B1 | NOVEL HETEROCYCLIC ANTIBIOTICS | HOFFMANN LA ROCHE (CH) | 2024-08-07 | — | — | EP | disclosed |
| WO-2024013308-A2 | METHOD OF REDUCING NITRO COMPOUNDS | THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW (GB) | 2024-01-18 | — | — | WO | disclosed |
| EP-3898630-B1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2023-05-10 | — | — | EP | disclosed |
| US-20230022724-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-01-26 | — | — | US | disclosed |
| US-20230017532-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-01-19 | — | — | US | disclosed |
| US-20230013602-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-01-19 | — | — | US | disclosed |
| EP-3898629-B1 | IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | HOFFMANN LA ROCHE (CH) | 2023-01-18 | — | — | EP | disclosed |
| EP-3898631-B1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS | HOFFMANN LA ROCHE (CH) | 2023-01-18 | — | — | EP | disclosed |
| US-20230012368-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-01-12 | — | — | US | disclosed |
| US-20230011869-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-01-12 | — | — | US | disclosed |
| US-4469882-A | FROM AROMATIC NITRO COMPOUND, ALCOHOL AND CARBON MONOXIDE | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) | 1984-09-04 | — | — | US | disclosed |
| EP-0001246-B1 | PREPARATION OF 2-(3'- OR 4'-AMINOPHENYL)-5(OR 6)-AMINOBENZIMIDAZOLES | CASSELLA Aktiengesellschaft (DE) | 1981-02-25 | — | — | EP | disclosed |
| US-4192947-A | REACTING DIAMINO NITROBENZENE WITH NITROBENZOYL CHLORIDE, CYCLIZING ANILIDE IN AQUEOUS ALKALI, REDUCING NITRO GROUPS WITH SULFIDE | CASSELLA AKTIENGESELLSCHAFT (DE) | 1980-03-11 | — | — | US | disclosed |
| US-4186269-A | REACTING AROMATIC NITRO COMPOUND, AN ALCOHOL, AND CARBON MONOXIDE IN PRESENCE OF CATALYST | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1980-01-29 | — | — | US | disclosed |
| US-4170708-A | FROM AN AROMATIC NITRO COMPOUND, AN ALCOHOL, AND CARBON MONOXIDE | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1979-10-09 | — | — | US | disclosed |
| EP-0001246-A1 | Preparation of 2-(3'- or 4'-aminophenyl)-5(or 6)-aminobenzimidazoles | CASSELLA Aktiengesellschaft (DE) | 1979-04-04 | — | — | EP | disclosed |
| US-4134880-A | Process for producing an aromatic urethane from nitro compounds, hydroxyl compounds and carbon monoxide using metal-Lewis acid-ammonia catalyst systems | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1979-01-16 | — | — | US | disclosed |
| US-4080365-A | Process for preparing aromatic urethanes | MITSUI TOATSU CHEMICALS (JA) | 1978-03-21 | — | — | US | disclosed |
| US-4070391-A | Process for producing isocyanate from nitro compounds and carbon monoxide using rhodium oxide catalysts | ETHYL CORPORATION (US) | 1978-01-24 | — | — | US | disclosed |
| US-4052437-A | PROCESS FOR PRODUCING URETHANE FROM NITRO COMPOUNDS, HYDROXYL COMPOUNDS AND CARBON MONOXIDE USING RHODIUM OXIDE CATALYSTS | ETHYL CORPORATION (US) | 1977-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230022724-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | MRPL21, O60361, MYD88 | ALDH1A1 539/4885TDP1 2111/4885CYP3A4 44/4885 |
| US-20230011869-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | MRPL21, O60361, MYD88 | ALDH1A1 539/4885TDP1 2111/4885CYP3A4 44/4885 |
| US-20230017532-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | MRPL21, O60361, MYD88 | ALDH1A1 540/4885TDP1 2117/4885CYP3A4 43/4885 |
| US-20230013602-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | IL4, RPS4Y1, RPS4X | ALDH1A1 1264/4885TDP1 3816/4885CYP3A4 5/4885 |
| US-20230012368-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | MRPL21, MYD88, IL1R1 | ALDH1A1 775/4885TDP1 2206/4885CYP3A4 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.