Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 9/20 | 0.49 |
| ▸ | DDB1 | Q16531 | 8/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23065973 | 0.85 | DDB1 (0.52) | CRBNDDB1MEN1KMT2ATSHR | |
| SCHEMBL25905759 | 0.84 | ALDH1A1 (0.47) | CRBNDDB1MEN1KMT2ATSHR | |
| SCHEMBL21408861 | 0.83 | TSHR (0.48) | CRBNDDB1MEN1KMT2ATSHR | |
| SCHEMBL30148827 | 0.83 | TSHR (0.48) | CRBNDDB1MEN1KMT2ATSHR | |
| SCHEMBL25575719 | 0.82 | CRBN (0.60) | CRBNDDB1ALDH1A1GAA | |
| SCHEMBL25575744 | 0.81 | CRBN (0.48) | CRBNDDB1MEN1KMT2AKDM4E | |
| SCHEMBL25122532 | 0.79 | CRBN (0.67) | CRBNDDB1MEN1KMT2ATSHR | |
| SCHEMBL25596152 | 0.77 | DDB1 (0.41) | CRBNDDB1MEN1KMT2APOLB | |
| SCHEMBL25074350 | 0.76 | CRBN (0.55) | CRBNDDB1MEN1KMT2AKDM4E | |
| SCHEMBL31607794 | 0.76 | CRBN (0.55) | CRBNDDB1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4393922-A1 | IRAK4 DEGRADATION AGENT, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Shanghai Leadingtac Pharmaceutical Co. Ltd. (CN) | 2024-07-03 | — | — | EP | disclosed |
| EP-4328219-A1 | SOS1 DEGRADING AGENT AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | Shanghai Leadingtac Pharmaceutical Co. Ltd. (CN) | 2024-02-28 | — | — | EP | disclosed |
| EP-4194457-A1 | COMPOUND FOR TARGETING AND DEGRADING PROTEIN, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Shanghai Leadingtac Pharmaceutical Co., Ltd. (CN) | 2023-06-14 | — | — | EP | disclosed |