Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.54 |
| ▸ | MAPK3 | P27361 | 4/20 | 0.54 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.52 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | ITK | Q08881 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2561547 | 0.88 | MAPK1 (0.69) | TTKMAPK1MAPK3HDAC6ITK | |
| SCHEMBL5822709 | 0.76 | MAPK3 (0.53) | TTKMAPK1MAPK3ERCC1ERCC4 | |
| SCHEMBL1402717 | 0.76 | BRD4 (0.55) | TTKMAPK1MAPK3HDAC1HDAC6 | |
| SCHEMBL758975 | 0.76 | ROCK2 (0.61) | ITKJAK2JAK1KDR | |
| SCHEMBL17871939 | 0.76 | KDM4E (0.58) | PPARG | |
| SCHEMBL12907294 | 0.75 | JAK2 (0.59) | TTKMAPK1MAPK3ITKJAK2 | |
| SCHEMBL2582534 | 0.75 | TTK (1.00) | TTK | |
| SCHEMBL12907302 | 0.75 | TTK (0.52) | TTKMAPK1MAPK3HDAC1JAK2 | |
| SCHEMBL12907304 | 0.75 | TTK (0.54) | TTKMAPK1MAPK3HDAC1HDAC6 | |
| SCHEMBL31203692 | 0.75 | MAPK1 (0.65) | TTKMAPK1MAPK3ITKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |