Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 7/20 | 0.69 |
| ▸ | MAPK3 | P27361 | 5/20 | 0.69 |
| ▸ | TTK | P33981 | 1/20 | 0.60 |
| ▸ | ITK | Q08881 | 1/20 | 0.58 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.49 |
| ▸ | AKT1 | P31749 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.49 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2557897 | 0.88 | TTK (0.60) | MAPK1MAPK3TTKITKCSNK2A2 | |
| SCHEMBL12907509 | 0.86 | MAPK1 (0.71) | MAPK1MAPK3TTKITKIMPDH2 | |
| SCHEMBL20217228 | 0.85 | MAPK1 (0.77) | MAPK1MAPK3TTKITKIMPDH2 | |
| SCHEMBL31203692 | 0.82 | MAPK1 (0.65) | MAPK1MAPK3TTKITKAKT1 | |
| SCHEMBL758975 | 0.81 | ROCK2 (0.61) | ITKIMPDH2KDRJAK2JAK1 | |
| SCHEMBL15400531 | 0.80 | MAPK1 (0.51) | MAPK1MAPK3TTKITKJAK2 | |
| SCHEMBL16292157 | 0.79 | LMNA (0.51) | MAPK1MAPK3TTKJAK2JAK1 | |
| SCHEMBL16292558 | 0.78 | MAPK1 (0.45) | MAPK1MAPK3TTKJAK2JAK1 | |
| SCHEMBL18108756 | 0.78 | MAPK1 (0.61) | MAPK1MAPK3TTKITKAKT1 | |
| SCHEMBL16292161 | 0.78 | MAPK1 (0.45) | MAPK1MAPK3TTKITKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |