Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL666126 | 0.87 | OPRM1 (0.53) | MEN1KMT2APOLBGAASMN1; SMN2 | |
| SCHEMBL23355845 | 0.85 | MEN1 (0.51) | MEN1KMT2APOLBGAASMN1; SMN2 | |
| SCHEMBL5141980 | 0.85 | MEN1 (0.51) | MEN1KMT2APOLBGAASMN1; SMN2 | |
| SCHEMBL4162403 | 0.84 | MEN1 (0.50) | MEN1KMT2APOLBGAASMN1; SMN2 | |
| SCHEMBL5508940 | 0.83 | POLB (0.60) | MEN1KMT2APOLBGAASMN1; SMN2 | |
| SCHEMBL2562392 | 0.81 | POLB (0.51) | MEN1KMT2APOLBGAASMN1; SMN2 | |
| SCHEMBL4036418 | 0.81 | GAA (0.54) | MEN1KMT2APOLBGAASMN1; SMN2 | |
| SCHEMBL2700566 | 0.80 | POLB (0.48) | MEN1KMT2APOLBGAASMN1; SMN2 | |
| SCHEMBL7715832 | 0.80 | POLQ (0.50) | MEN1KMT2APOLBGAASMN1; SMN2 | |
| SCHEMBL30528370 | 0.80 | POLB (0.50) | MEN1KMT2APOLBGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132048-A1 | HETEROARYL COMPOUNDS AS PDE10A INHIBITORS | GLENMARK PHARMACEUTICAL S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |
| WO-2011132048-A1 | HETEROARYL COMPOUNDS AS PDE10A INHIBITORS | GLENMARK PHARMACEUTICAL S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |
| EP-2010493-A2 | PYRIDYL AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | Merck & Co., Inc. (US) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007120729-A2 | PYRIDYL AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK & CO., INC. (US) | 2007-10-25 | — | — | WO | disclosed |