SCHEMBL2558355

SCHEMBL2558355

O=Cc1c(-c2cccc(Cl)c2)nn(-c2ccccc2F)c1Cl

nearest known ligand 0.38

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.38
GRM5 P41594 1/20 0.37
NPSR1 Q6W5P4 1/20 0.36
MGLL Q99685 1/20 0.36
PIK3CG P48736 1/20 0.36
MDM2 Q00987 2/20 0.36
MDM4 O15151 1/20 0.36
SCN9A Q15858 2/20 0.35
HPGD P15428 1/20 0.35
KMT2A Q03164 1/20 0.35
IDO1 P14902 1/20 0.34
KCNN4 O15554 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
ADORA2A P29274 1/20 0.33
ADORA1 P30542 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15331264 0.90 PTGER1 (0.35) SCN9AHPGDKMT2AKCNN4
SCHEMBL2556378 0.89 HPGD (0.36) MDM2MDM4HPGDKMT2AKCNN4
SCHEMBL15331113 0.89 HPGD (0.39) NPSR1HPGDKMT2AKCNN4
SCHEMBL15331900 0.88 PIK3CG (0.37) MAPTGRM5NPSR1MGLLPIK3CG
SCHEMBL15330615 0.86 GAA (0.39) NPSR1HPGDKMT2AKCNN4
SCHEMBL2560002 0.85 TMEM97 (0.37) MDM2MDM4HPGDKMT2AKCNN4
SCHEMBL2555814 0.84 NPC1 (0.42) MAPTNPSR1KMT2A
SCHEMBL2556623 0.84 POLB (0.41) NPSR1HPGDKMT2AKCNN4
SCHEMBL15329895 0.83 KMT2A (0.39) MAPTMGLLMDM2MDM4HPGD
SCHEMBL2559787 0.83 ESR1 (0.36) GRM5SCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed
EP-2558577-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2013-02-20 EP disclosed
WO-2011127933-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2011-10-20 WO disclosed