Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.52 |
| ▸ | MEN1 | O00255 | 9/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.52 |
| ▸ | POLB | P06746 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 2/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2557544 | 0.91 | TTK (0.63) | TTKKMT2AMEN1SMN1; SMN2POLB | |
| SCHEMBL4146278 | 0.75 | TTK (0.58) | TTKKMT2AMEN1SMN1; SMN2POLB | |
| SCHEMBL1461383 | 0.75 | GSK3B (0.64) | TTKKMT2AMEN1SMN1; SMN2POLB | |
| SCHEMBL25243779 | 0.75 | ITK (0.43) | TTKAURKA | |
| SCHEMBL2554976 | 0.74 | MEN1 (0.61) | TTKKMT2AMEN1SMN1; SMN2POLB | |
| SCHEMBL2861303 | 0.74 | TTK (0.75) | TTKKMT2AMEN1SMN1; SMN2POLB | |
| SCHEMBL2588127 | 0.72 | TTK (1.00) | TTKAURKBCYP2C9CA12CA1 | |
| SCHEMBL12281383 | 0.71 | TTK (0.85) | TTKAURKAAURKBCYP2C9 | |
| SCHEMBL4502111 | 0.71 | GSK3B (0.57) | AURKAAURKBCYP1A2 | |
| SCHEMBL2569096 | 0.71 | TTK (0.60) | TTKKMT2AMEN1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123937-A1 | KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-13 | — | — | WO | disclosed |