Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | CMA1 | P23946 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL692247 | 1.00 | HTR2C (0.45) | HTR2CHTR2AHTR2BDRD2AHR | |
| SCHEMBL1350944 | 0.82 | HTR2A (0.50) | HTR2CHTR2AHTR2BDRD2ALDH1A1 | |
| SCHEMBL691879 | 0.80 | DRD2 (0.48) | HTR2CDRD2 | |
| SCHEMBL2018357 | 0.79 | CNR1 (0.42) | HTR2C | |
| SCHEMBL2018349 | 0.79 | HTR2C (0.65) | HTR2CHTR2AHTR2BALDH1A1 | |
| SCHEMBL691270 | 0.79 | HTR2C (0.65) | HTR2CHTR2AHTR2BALDH1A1 | |
| SCHEMBL5917470 | 0.74 | POLB (0.49) | HTR2CHTR2AHTR2BDRD2POLB | |
| SCHEMBL2013376 | 0.73 | DRD2 (0.48) | HTR2CHTR2AHTR2BDRD2HTR1A | |
| SCHEMBL2014167 | 0.73 | DRD2 (0.48) | HTR2CHTR2AHTR2BDRD2HTR1A | |
| SCHEMBL2017462 | 0.73 | HTR2A (0.39) | HTR2CHTR2AHTR2BDRD2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560973-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbvie Inc. (US) | 2013-02-27 | — | — | EP | claimed |
| WO-2011133182-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-10-27 | — | — | WO | claimed |
| EP-2560973-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbvie Inc. (US) | 2013-02-27 | — | — | EP | disclosed |
| WO-2011133182-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-10-27 | — | — | WO | disclosed |