Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | PRMT1 | Q99873 | 4/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | GFER | P55789 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | NAMPT | P43490 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.55 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.55 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.55 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amidapsone SCHEMBL164971 | 0.85 | PKM (0.72) | PRMT1MAPTLMNACYP2C19CYP3A4 | |
| SCHEMBL27489561 | 0.85 | KMT2A (0.69) | KMT2AMEN1HPGDPRMT1MAPT | |
| SCHEMBL28813739 | 0.84 | CA1 (0.60) | KMT2AMEN1PRMT1MAPTNAMPT | |
| SCHEMBL12010905 | 0.83 | CA12 (0.71) | KMT2AMEN1HPGDPRMT1MAPT | |
| SCHEMBL28177667 | 0.82 | ABCC9 (0.63) | KMT2AMEN1HPGDMAPTLMNA | |
| SCHEMBL14534640 | 0.81 | PKM (0.74) | KMT2AMEN1HPGDPRMT1MAPT | |
| SCHEMBL9913185 | 0.81 | CA12 (0.73) | KMT2AMEN1HPGDPRMT1MAPT | |
| SCHEMBL20809563 | 0.81 | CA1 (0.77) | KMT2AMEN1MAPTGAAGFER | |
| SCHEMBL11033332 | 0.81 | CA1 (0.68) | KMT2AMEN1HPGDPRMT1MAPT | |
| Phenylurea SCHEMBL54471 | 0.80 | GAA (0.83) | KMT2AMEN1MAPTGAAGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100536839-C | Urea derivatives as integrin alpha 4 antagonists | ALMIRALL PRODESFARMA SA (ES) | 2009-09-09 | — | — | CN | claimed |
| CN-1531425-A | Urea derivatives as integrin alpha 4 antagonists | ������ҩ������˾ | 2004-09-22 | — | — | CN | claimed |
| CN-106986856-A | It is used as 4 { [(ylmethyl of pyridine 3) amino carbonyl] amino } Benzosulfone derivatives of the NAMPT inhibitor for treating diseases such as cancer | 福马TM有限责任公司 | 2017-07-28 | — | — | CN | disclosed |
| CN-103270023-B | 4- { [ (pyridin-3-yl-methyl) aminocarbonyl ] amino } benzene-sulfone derivatives as NAMPT inhibitors for the treatment of diseases such as cancer | 福马TM有限责任公司 | 2016-11-02 | — | — | CN | disclosed |
| CN-103270023-A | 4- { [ (pyridin-3-yl-methyl) aminocarbonyl ] amino } benzene-sulfone derivatives as NAMPT inhibitors for the treatment of diseases such as cancer | FORMA THERAPEUTICS INC | 2013-08-28 | — | — | CN | disclosed |
| WO-2012031196-A1 | 4- { [ ( PYRIDIN- 3 - YL -METHYL) AMINOCARBONYL] AMINO} BENZENE - SULFONE DERIVATIVES AS NAMPT INHIBITORS FOR THERAPY OF DISEASES SUCH AS CANCER | FORMA THERAPEUTICS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |
| CN-100536839-C | Urea derivatives as integrin alpha 4 antagonists | ALMIRALL PRODESFARMA SA (ES) | 2009-09-09 | — | — | CN | disclosed |
| CN-1531425-A | Urea derivatives as integrin alpha 4 antagonists | ������ҩ������˾ | 2004-09-22 | — | — | CN | disclosed |