Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.64 |
| ▸ | AR | P10275 | 5/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 7/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043279 | 0.83 | RAB9A (0.61) | RAB9ASMN1; SMN2ARTP53ALOX15 | |
| SCHEMBL14183837 | 0.81 | SMN1; SMN2 (0.72) | RAB9ASMN1; SMN2ARTP53ALOX15 | |
| SCHEMBL7369256 | 0.80 | HTR2A (0.56) | RAB9ASMN1; SMN2TP53ALOX15HSD17B10 | |
| SCHEMBL2558958 | 0.80 | SMN1; SMN2 (0.74) | RAB9ASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL12289897 | 0.80 | SMN1; SMN2 (0.58) | RAB9ASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL12632067 | 0.80 | ALDH1A1 (0.56) | RAB9ASMN1; SMN2ARTP53ALOX15 | |
| SCHEMBL12669971 | 0.80 | ALDH1A1 (0.56) | RAB9ASMN1; SMN2ARTP53ALOX15 | |
| SCHEMBL2157208 | 0.79 | ALDH1A1 (0.58) | RAB9ASMN1; SMN2ARTP53ALOX15 | |
| SCHEMBL19627013 | 0.79 | RAB9A (0.60) | RAB9ASMN1; SMN2ARTP53ALOX15 | |
| SCHEMBL12288921 | 0.79 | RAB9A (1.00) | RAB9ASMN1; SMN2ARTP53ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130515-A1 | ARYLTHIAZOLYL PIPERIDINES AND RELATED COMPOUNDS AS MODULATORS OF SURVIVAL MOTOR NEURON (SMN) PROTEIN PRODUCTION | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-10-20 | — | — | WO | disclosed |