Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.46 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | BRAF | P15056 | 6/20 | 0.43 |
| ▸ | GCK | P35557 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2562402 | 0.87 | SMN1; SMN2 (0.46) | MAPK14MEN1KMT2ABRAFGCK | |
| SCHEMBL23795609 | 0.82 | HTT (0.49) | MAPK14MAPK13MEN1KMT2ABRAF | |
| SCHEMBL29397232 | 0.81 | MEN1 (0.44) | MAPK14MAPK13MEN1KMT2ABRAF | |
| SCHEMBL13788542 | 0.81 | HTT (0.56) | MAPK14MAPK13MEN1KMT2ABRAF | |
| SCHEMBL29083255 | 0.78 | MEN1 (0.45) | MAPK14MEN1KMT2ABRAFGCK | |
| SCHEMBL16037109 | 0.77 | MAPK14 (0.46) | MAPK14MAPK13MEN1KMT2ABRAF | |
| SCHEMBL29662429 | 0.77 | MAPK14 (0.49) | MAPK14MEN1KMT2AGCKKDR | |
| SCHEMBL2562936 | 0.77 | MAPK14 (0.49) | MAPK14MEN1KMT2AGCKKDR | |
| SCHEMBL23795622 | 0.75 | MEN1 (0.43) | MAPK14MAPK13PIK3C3MEN1KMT2A | |
| SCHEMBL23795626 | 0.75 | MEN1 (0.43) | MAPK14MEN1KMT2ABRAFGCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2556065-A1 | PYRAZOLE P38 MAP KINASE INHIBITORS | Respivert Limited (GB) | 2013-02-13 | — | — | EP | disclosed |
| WO-2011121366-A1 | PYRAZOLE P38 MAP KINASE INHIBITORS | RESPIVERT LIMITED (GB) | 2011-10-06 | — | — | WO | disclosed |