Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 6/20 | 0.78 |
| ▸ | KDR | P35968 | 4/20 | 0.78 |
| ▸ | JAK2 | O60674 | 3/20 | 0.78 |
| ▸ | ABL1 | P00519 | 3/20 | 0.78 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.78 |
| ▸ | LCK | P06239 | 3/20 | 0.78 |
| ▸ | LYN | P07948 | 3/20 | 0.78 |
| ▸ | RET | P07949 | 3/20 | 0.78 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.78 |
| ▸ | KIT | P10721 | 3/20 | 0.78 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.78 |
| ▸ | CDK4 | P11802 | 3/20 | 0.78 |
| ▸ | SRC | P12931 | 3/20 | 0.78 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.78 |
| ▸ | CCND1 | P24385 | 3/20 | 0.78 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.78 |
| ▸ | CDK2 | P24941 | 3/20 | 0.78 |
| ▸ | FLT3 | P36888 | 3/20 | 0.78 |
| ▸ | CDK7 | P50613 | 3/20 | 0.78 |
| ▸ | BLK | P51451 | 3/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14845612 | 0.88 | PRKCZ (1.00) | PRKCZKDRJAK2ABL1ERBB2 | |
| SCHEMBL20333841 | 0.88 | PRKCZ (1.00) | PRKCZKDRJAK2ABL1ERBB2 | |
| SCHEMBL18808417 | 0.88 | PRKCZ (1.00) | PRKCZKDRJAK2ABL1ERBB2 | |
| SCHEMBL24606232 | 0.88 | PRKCZ (1.00) | PRKCZKDRJAK2ABL1ERBB2 | |
| SCHEMBL23259513 | 0.85 | PRKCZ (0.71) | PRKCZKDRJAK2ABL1ERBB2 | |
| SCHEMBL12632187 | 0.82 | PRKCQ (0.70) | PRKCZKDRJAK2ABL1ERBB2 | |
| SCHEMBL24105686 | 0.82 | PRKCQ (0.69) | PRKCZKDRJAK2ABL1ERBB2 | |
| SCHEMBL22970010 | 0.82 | PRKCQ (0.69) | PRKCZKDRJAK2ABL1ERBB2 | |
| SCHEMBL16946994 | 0.82 | PRKCQ (0.69) | PRKCZKDRJAK2ABL1ERBB2 | |
| SCHEMBL20048217 | 0.82 | PRKCQ (0.69) | PRKCZKDRJAK2ABL1ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4186895-A1 | COMPOUND USEFUL AS CDK7 KINASE INHIBITOR AND USE THEREOF | TYK Medicines Inc. (CN) | 2023-05-31 | — | — | EP | disclosed |