Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 1/20 | 0.62 |
| ▸ | PDE5A | O76074 | 15/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | PDE1A | P54750 | 4/20 | 0.51 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.51 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29732712 | 0.81 | MEN1 (0.70) | GUSBPDE5AKDM4EMEN1KMT2A | |
| SCHEMBL4196255 | 0.81 | MEN1 (0.70) | GUSBPDE5AKDM4EMEN1KMT2A | |
| SCHEMBL2559792 | 0.81 | GUSB (0.59) | GUSBPDE5AKDM4EPDE1APDE1B | |
| SCHEMBL16198803 | 0.79 | PDE5A (0.71) | PDE5A | |
| SCHEMBL2568411 | 0.77 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CPDE10A | |
| SCHEMBL31238756 | 0.77 | GUSB (1.00) | GUSBPDE5AKDM4EPDE1APDE1B | |
| SCHEMBL7160589 | 0.77 | GUSB (1.00) | GUSBPDE5AKDM4EPDE1APDE1B | |
| SCHEMBL2567731 | 0.77 | PDE5A (0.61) | GUSBPDE5AKDM4EPDE1APDE1B | |
| SCHEMBL8677237 | 0.77 | XDH (0.68) | KDM4EMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL2564559 | 0.75 | GUSB (0.58) | GUSBPDE5AKDM4EPDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2383262-B1 | PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF | TOPHARMAN SHANGHAI CO LTD (CN) | 2016-07-06 | — | — | EP | disclosed |
| EP-2383262-B1 | PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF | TOPHARMAN SHANGHAI CO LTD (CN) | 2016-07-06 | — | — | EP | disclosed |
| US-8871777-B2 | Phenylpyrimidone compounds, the pharmaceutical compositions, preparation methods and uses thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2014-10-28 | — | — | US | disclosed |
| US-8871777-B2 | Phenylpyrimidone compounds, the pharmaceutical compositions, preparation methods and uses thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2014-10-28 | — | — | US | disclosed |
| US-8871777-B2 | Phenylpyrimidone compounds, the pharmaceutical compositions, preparation methods and uses thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2014-10-28 | — | — | US | disclosed |
| EP-2383262-A1 | PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF | Topharman Shanghai Co., Ltd. (CN) | 2011-11-02 | — | — | EP | disclosed |