Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 6/20 | 0.60 |
| ▸ | CCNK | O75909 | 6/20 | 0.60 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.60 |
| ▸ | CDK2 | P24941 | 6/20 | 0.60 |
| ▸ | CDK9 | P50750 | 6/20 | 0.60 |
| ▸ | CDK12 | Q9NYV4 | 6/20 | 0.60 |
| ▸ | CDK7 | P50613 | 8/20 | 0.50 |
| ▸ | CCNH | P51946 | 8/20 | 0.50 |
| ▸ | MNAT1 | P51948 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 4/20 | 0.38 |
| ▸ | JAK2 | O60674 | 4/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25598680 | 0.87 | CCNT1 (0.60) | CCNT1CCNKCCNE1CDK2CDK9 | |
| SCHEMBL15648351 | 0.77 | CDK2 (0.55) | CCNT1CCNKCCNE1CDK2CDK9 | |
| SCHEMBL24839463 | 0.76 | CCNK (1.00) | CCNT1CCNKCCNE1CDK2CDK9 | |
| SCHEMBL8943361 | 0.69 | JAK2 (0.49) | CCNT1CCNKCCNE1CDK2CDK9 | |
| SCHEMBL24900582 | 0.69 | RPS6KA5 (0.60) | CCNT1CCNKCCNE1CDK2CDK9 | |
| SCHEMBL30007128 | 0.68 | CCNT1 (0.43) | CCNT1CCNKCCNE1CDK2CDK9 | |
| SCHEMBL28817278 | 0.68 | CCNT1 (0.43) | CCNT1CCNKCCNE1CDK2CDK9 | |
| SCHEMBL24900631 | 0.67 | RPS6KA5 (0.48) | CCNT1CCNKCCNE1CDK2CDK9 | |
| SCHEMBL30957452 | 0.67 | RPS6KA5 (0.48) | CCNT1CCNKCCNE1CDK2CDK9 | |
| SCHEMBL24900677 | 0.67 | CCNT1 (0.55) | CCNT1CCNKCCNE1CDK2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4295852-A2 | PIPERIDINE DERIVATIVES AS INHIBITORS OF CYCLIN DEPENDENT KINASE 7 (CDK7) | Syros Pharmaceuticals, Inc. (US) | 2023-12-27 | — | — | EP | disclosed |
| EP-3484871-B1 | PIPERIDINE DERIVATIVES AS INHIBITORS OF CYCLIN DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS INC (US) | 2023-06-07 | — | — | EP | disclosed |