Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 8/20 | 0.47 |
| ▸ | CCNH | P51946 | 8/20 | 0.47 |
| ▸ | MNAT1 | P51948 | 7/20 | 0.47 |
| ▸ | CCNK | O75909 | 9/20 | 0.46 |
| ▸ | CDK12 | Q9NYV4 | 9/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.46 |
| ▸ | CDK2 | P24941 | 4/20 | 0.46 |
| ▸ | CDK9 | P50750 | 4/20 | 0.46 |
| ▸ | GUSB | P08236 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.39 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25600700 | 0.85 | CCNK (0.48) | CDK7CCNHMNAT1CCNKCDK12 | |
| SCHEMBL28817250 | 0.83 | CCNK (0.48) | CDK7CCNHMNAT1CCNKCDK12 | |
| SCHEMBL25600703 | 0.83 | CLK1 (0.52) | CDK7CCNHMNAT1CCNKCDK12 | |
| SCHEMBL25599273 | 0.82 | CCNK (0.60) | CDK7CCNHMNAT1CCNKCDK12 | |
| SCHEMBL30007191 | 0.80 | CCNK (0.60) | CDK7CCNHMNAT1CCNKCDK12 | |
| SCHEMBL21178905 | 0.80 | CCNK (0.60) | CDK7CCNHMNAT1CCNKCDK12 | |
| SCHEMBL17542563 | 0.80 | CDK7 (0.54) | CDK7CCNHMNAT1KITEGFR | |
| SCHEMBL30957576 | 0.80 | CDK7 (0.54) | CDK7CCNHMNAT1KITEGFR | |
| SCHEMBL30375181 | 0.73 | DYRK1A (0.52) | PDE4BEGFRTDO2MAP3K14 | |
| SCHEMBL20680053 | 0.73 | DYRK1A (0.52) | PDE4BEGFRTDO2MAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484871-B1 | PIPERIDINE DERIVATIVES AS INHIBITORS OF CYCLIN DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS INC (US) | 2023-06-07 | — | — | EP | disclosed |
| CN-110036004-A | Inhibitors of cyclin dependent kinase 7(CDK7) | 希洛斯医药品股份有限公司 | 2019-07-19 | — | — | CN | disclosed |