Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 12/20 | 0.48 |
| ▸ | CDK12 | Q9NYV4 | 12/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 6/20 | 0.48 |
| ▸ | CDK9 | P50750 | 6/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.48 |
| ▸ | CDK2 | P24941 | 5/20 | 0.48 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.47 |
| ▸ | CDK7 | P50613 | 11/20 | 0.42 |
| ▸ | CCNH | P51946 | 11/20 | 0.42 |
| ▸ | MNAT1 | P51948 | 10/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21628998 | 0.86 | MAP3K14 (0.52) | CCNKCDK12CCNT1CDK9CCNE1 | |
| SCHEMBL30554763 | 0.86 | MAP3K14 (0.52) | CCNKCDK12CCNT1CDK9CCNE1 | |
| SCHEMBL25600703 | 0.86 | CLK1 (0.52) | CCNKCDK12CCNT1CDK9CCNE1 | |
| SCHEMBL28817250 | 0.86 | CCNK (0.48) | CCNKCDK12CCNT1CDK9CCNE1 | |
| SCHEMBL25599273 | 0.85 | CCNK (0.60) | CCNKCDK12CCNT1CDK9CCNE1 | |
| SCHEMBL25599698 | 0.85 | CDK7 (0.47) | CCNKCDK12CCNT1CDK9CCNE1 | |
| SCHEMBL30007191 | 0.83 | CCNK (0.60) | CCNKCDK12CCNT1CDK9CCNE1 | |
| SCHEMBL21178905 | 0.83 | CCNK (0.60) | CCNKCDK12CCNT1CDK9CCNE1 | |
| SCHEMBL19532565 | 0.80 | DYRK1A (0.51) | MAP3K14PDE4B | |
| SCHEMBL30108168 | 0.78 | JAK2 (0.55) | CCNKCDK12CCNT1CDK9MAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484871-B1 | PIPERIDINE DERIVATIVES AS INHIBITORS OF CYCLIN DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS INC (US) | 2023-06-07 | — | — | EP | disclosed |