Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 6/20 | 0.41 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.39 |
| ▸ | CDK7 | P50613 | 3/20 | 0.39 |
| ▸ | CCNH | P51946 | 3/20 | 0.39 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | CCNK | O75909 | 2/20 | 0.38 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 3/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 2/20 | 0.35 |
| ▸ | CTSB | P07858 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25599228 | 0.91 | UCHL3 (0.40) | CTSCUCHL3CCNA2CDK2CDK7 | |
| SCHEMBL25599226 | 0.89 | BTK (0.43) | CTSCUCHL3CCNA2CDK2CDK7 | |
| SCHEMBL25599169 | 0.88 | CTSC (0.47) | CTSCUCHL3CCNA2CDK2CDK7 | |
| SCHEMBL25682250 | 0.88 | CTSC (0.47) | CTSCUCHL3CCNA2CDK2CDK7 | |
| SCHEMBL25599220 | 0.85 | UCHL3 (0.39) | CTSCUCHL3CCNA2CDK2CDK7 | |
| SCHEMBL25682448 | 0.83 | CCNA2 (0.39) | CTSCUCHL3CCNA2CDK2CDK7 | |
| SCHEMBL25599216 | 0.83 | CCNA2 (0.39) | CTSCUCHL3CCNA2CDK2CDK7 | |
| SCHEMBL25682533 | 0.83 | CCNA2 (0.39) | CTSCUCHL3CCNA2CDK2CDK7 | |
| SCHEMBL25681380 | 0.81 | CTSC (0.40) | CTSCUCHL3CCNA2CDK2CDK7 | |
| SCHEMBL25599412 | 0.81 | CTSC (0.40) | CTSCUCHL3CCNA2CDK2CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023102184-A1 | BICYCLIC AMINE COMPOUNDS AS CDK12 INHIBITORS | INCYTE CORPORATION (US) | 2023-06-08 | — | — | WO | disclosed |