Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 8/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2559970 | 0.80 | IDO1 (0.39) | ERN1KDM4EIDO1CYP17A1CYP19A1 | |
| SCHEMBL4737860 | 0.79 | KDM5A (0.59) | KDM4EMEN1NPC1HSP90AA1IDO1 | |
| SCHEMBL2556489 | 0.77 | CYP19A1 (0.40) | KDM4EMEN1KMT2ANPSR1CYP19A1 | |
| SCHEMBL2556065 | 0.77 | PDE4B (0.43) | IDO1CYP17A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL2559729 | 0.76 | CCNC (0.44) | NPC1RAB9A | |
| SCHEMBL2559731 | 0.76 | CCNC (0.44) | NPC1RAB9A | |
| SCHEMBL29890504 | 0.72 | ERN1 (0.53) | ERN1KDM4EMEN1NPC1HSP90AA1 | |
| SCHEMBL26933519 | 0.72 | ERN1 (0.53) | ERN1KDM4EMEN1NPC1HSP90AA1 | |
| SCHEMBL2795791 | 0.69 | KDM5A (0.38) | ERN1KDM4EMEN1NPC1HSP90AA1 | |
| SCHEMBL2556718 | 0.69 | CYP17A1 (0.39) | ERN1KDM4ENPC1RAB9AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |