Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 4/20 | 0.31 |
| ▸ | IDO1 | P14902 | 2/20 | 0.31 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.30 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2562661 | 0.90 | PDE4B (0.52) | PDE4BPDE4DPDE4APDE4CCYP17A1 | |
| SCHEMBL7707992 | 0.84 | PDE4B (0.43) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL2559970 | 0.84 | IDO1 (0.39) | PDE4BPDE4DPDE4APDE4CTDO2 | |
| SCHEMBL8169795 | 0.82 | PDE4B (0.43) | PDE4BPDE4DPDE4APDE4CCYP17A1 | |
| SCHEMBL2556489 | 0.81 | CYP19A1 (0.40) | CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL2563026 | 0.79 | CCNC (0.40) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL2560102 | 0.77 | ERN1 (0.43) | TDO2IDO1CYP17A1CYP19A1CYP11B1 | |
| SCHEMBL7970312 | 0.76 | PDE4B (0.36) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL14308379 | 0.76 | SMN1; SMN2 (0.37) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL2792898 | 0.74 | PDE4A (0.32) | PDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |