Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.70 |
| ▸ | NPC1 | O15118 | 5/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | ABL1 | P00519 | 3/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2558952 | 0.90 | NPC1 (0.88) | RAB9ANPC1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL2557032 | 0.90 | KDM4E (0.56) | RAB9ANPC1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL2562338 | 0.83 | RAB9A (0.63) | RAB9ANPC1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL2559105 | 0.82 | RAB9A (0.61) | RAB9ANPC1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL2558907 | 0.82 | ABL1 (0.65) | RAB9ANPC1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL2557829 | 0.82 | RAB9A (0.61) | RAB9ANPC1SMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL2557289 | 0.82 | RAB9A (0.61) | RAB9ANPC1SMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL2559658 | 0.81 | RAB9A (0.61) | RAB9ANPC1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL2560567 | 0.81 | MKNK1 (0.57) | RAB9ANPC1ABL1SLC5A1 | |
| SCHEMBL2557275 | 0.81 | SLC5A1 (0.48) | RAB9ANPC1ABL1SLC5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130515-A1 | ARYLTHIAZOLYL PIPERIDINES AND RELATED COMPOUNDS AS MODULATORS OF SURVIVAL MOTOR NEURON (SMN) PROTEIN PRODUCTION | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-10-20 | — | — | WO | claimed |