Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.88 |
| ▸ | RAB9A | P51151 | 2/20 | 0.88 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.56 |
| ▸ | ATP4A | P20648 | 2/20 | 0.55 |
| ▸ | ATP4B | P51164 | 2/20 | 0.55 |
| ▸ | GSK3A | P49840 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | CDC25A | P30304 | 1/20 | 0.55 |
| ▸ | CDC25B | P30305 | 1/20 | 0.55 |
| ▸ | CDC25C | P30307 | 1/20 | 0.55 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2560153 | 0.90 | RAB9A (0.70) | NPC1RAB9AALDH1A1HPGDHTT | |
| SCHEMBL2559385 | 0.89 | RAB9A (0.69) | NPC1RAB9AALDH1A1HPGDHTT | |
| SCHEMBL2553329 | 0.88 | RAB9A (0.67) | NPC1RAB9AALDH1A1HPGDHTT | |
| SCHEMBL2562338 | 0.85 | RAB9A (0.63) | NPC1RAB9AALDH1A1HPGDHTT | |
| SCHEMBL2558080 | 0.84 | MEN1 (0.68) | NPC1RAB9AALDH1A1HPGDHSD17B10 | |
| SCHEMBL2557289 | 0.84 | RAB9A (0.61) | NPC1RAB9AALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL2557829 | 0.84 | RAB9A (0.61) | NPC1RAB9AALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL2559105 | 0.84 | RAB9A (0.61) | NPC1RAB9AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL2558907 | 0.84 | ABL1 (0.65) | NPC1RAB9AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL2559658 | 0.83 | RAB9A (0.61) | NPC1RAB9AALDH1A1HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130515-A1 | ARYLTHIAZOLYL PIPERIDINES AND RELATED COMPOUNDS AS MODULATORS OF SURVIVAL MOTOR NEURON (SMN) PROTEIN PRODUCTION | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-10-20 | — | — | WO | claimed |