⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5523562 | 1.00 | — | — | |
| SCHEMBL22182586 | 1.00 | — | — | |
| SCHEMBL23198921 | 0.90 | HCAR2 (0.43) | — | |
| SCHEMBL23671880 | 0.90 | HCAR2 (0.43) | — | |
| SCHEMBL23671855 | 0.90 | HCAR2 (0.43) | — | |
| SCHEMBL23671857 | 0.90 | HCAR2 (0.43) | — | |
| SCHEMBL13618771 | 0.83 | HCAR2 (0.48) | — | |
| SCHEMBL21392011 | 0.80 | MAPT (0.51) | — | |
| SCHEMBL20634195 | 0.80 | MAPT (0.51) | — | |
| SCHEMBL3688382 | 0.80 | MAPT (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633704-A2 | INTERMEDIATES USEFUL IN THE SYNTHESIS OF HIV-PROTEASE INHIBITORS AND METHODS FOR PREPARING THE SAME | PFIZER INC. (US) | 2006-03-15 | — | — | EP | claimed |
| US-20050250949-A1 | Intermediates useful in the synthesis of HIV-protease inhibitors and methods for preparing the same | AGOURON PHARMACEUTICALS INC. | 2005-11-10 | — | — | US | claimed |
| WO-2004099129-A2 | INTERMEDIATES USEFUL IN THE SYNTHESIS OF HIV-PROTEASE INHIBITORS AND METHODS FOR PREPARING THE SAME | PFIZER INC. (US) | 2004-11-18 | — | — | WO | claimed |
| US-10611732-B2 | HIV replication inhibiting pyrimidines | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-07 | — | — | US | disclosed |
| US-20190322628-A1 | HIV REPLICATION INHIBITING PYRIMIDINES | JANSSEN PHARMACEUTICA NV (BE) | 2019-10-24 | — | — | US | disclosed |
| US-9765065-B2 | Therapeutic substituted cyclopentanes | ALLERGAN, INC. (US) | 2017-09-19 | — | — | US | disclosed |
| US-20170144999-A1 | THERAPEUTIC SUBSTITUTED CYCLOPENTANES | ALLERGAN, INC. | 2017-05-25 | — | — | US | disclosed |
| EP-2285775-B1 | Lactams and their use in the treatment of inter alia ocular hypertension or baldness | ALLERGAN INC (US) | 2017-03-22 | — | — | EP | disclosed |
| US-9591935-B2 | Therapeutic substituted cyclopentanes | ALLERGEN, INC. (US) | 2017-03-14 | — | — | US | disclosed |
| EP-2593493-B1 | CONJUGATED POLYMERIC SYSTEMS AND APPLICATIONS THEREOF | UNIV WAKE FOREST (US) | 2017-01-25 | — | — | EP | disclosed |
| US-9365485-B2 | Substituted arylcyclopentenes as therapeutic agents | ALLERGAN, INC. (US) | 2016-06-14 | — | — | US | disclosed |
| US-20080058387-A1 | 5-(3-(3-(4-(1-hydroxyhexyl)phenyl)-4-oxo-thiazolidin-2-yl)propyl)thiophene-2-carboxylic acid; prostaglandin agonist; ocular hypotensive agents; post-surgical and post-laser trabeculectomy ocular hypertensive episodes, glaucoma, and as presurgical adjuncts | ALLERGAN, INC. | 2008-03-06 | — | — | US | disclosed |
| US-20080058397-A1 | 5-(3-(3-(4-hexanoylphenyl)-2,5-dioxoimidazolidin-4-yl)propyl)thiophene-2-carboxylic acid; prostaglandin agonist; ocular hypotensive agent; post-sergical and post-laser trabeculectomy ocular hypertensive episodes, glaucoma, and as presurgical adjuncts | OLD DAVID W | 2008-03-06 | — | — | US | disclosed |
| US-20080051374-A1 | Therapeutic Amides and related Compounds | ALLERGAN, INC. | 2008-02-28 | — | — | US | disclosed |
| US-20080039505-A1 | THERAPEUTIC LACTAMS | ALLERGAN, INC. | 2008-02-14 | — | — | US | disclosed |
| US-7173059-B2 | Intermediates useful in the synthesis of HIV-protease inhibitors and methods for preparing the same | AGOURON PHARMACEUTICALS, INC. (US) | 2007-02-06 | — | — | US | disclosed |
| CN-1819993-A | Intermediates for the synthesis of HIV-protease inhibitors and processes for their preparation | PFIZER (US) | 2006-08-16 | — | — | CN | disclosed |
| EP-1633704-A2 | INTERMEDIATES USEFUL IN THE SYNTHESIS OF HIV-PROTEASE INHIBITORS AND METHODS FOR PREPARING THE SAME | PFIZER INC. (US) | 2006-03-15 | — | — | EP | disclosed |
| US-20050250949-A1 | Intermediates useful in the synthesis of HIV-protease inhibitors and methods for preparing the same | AGOURON PHARMACEUTICALS INC. | 2005-11-10 | — | — | US | disclosed |
| WO-2004099129-A2 | INTERMEDIATES USEFUL IN THE SYNTHESIS OF HIV-PROTEASE INHIBITORS AND METHODS FOR PREPARING THE SAME | PFIZER INC. (US) | 2004-11-18 | — | — | WO | disclosed |