Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 4/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25604065 | 0.89 | MEN1 (0.42) | HCRTR1DRD4NPC1RAB9A | |
| SCHEMBL25604567 | 0.89 | MCHR1 (0.37) | KDM4EALDH1A1HSD17B10PDE4BPDE4D | |
| SCHEMBL25604224 | 0.88 | DRD4 (0.36) | KDM4EALDH1A1HSD17B10PDE4BPDE4D | |
| SCHEMBL25604078 | 0.87 | KMT2A (0.42) | KDM4EL3MBTL1PDE4BHCRTR1NPC1 | |
| SCHEMBL25604714 | 0.87 | DRD3 (0.42) | TYK2PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL25606159 | 0.86 | ADRA2A (0.45) | KDM4EALDH1A1HSD17B10PDE4BPDE4D | |
| SCHEMBL25604073 | 0.86 | PDE4B (0.37) | KDM4EALDH1A1HSD17B10PDE4BPDE4D | |
| SCHEMBL25604145 | 0.86 | NPC1 (0.41) | ADRA1APDE4BPDE4DPDE4APDE4C | |
| SCHEMBL25604123 | 0.85 | NPC1 (0.51) | ADRA1AKDM4EALDH1A1HSD17B10PDE4B | |
| SCHEMBL25605157 | 0.85 | NPC1 (0.40) | ADRA1AKDM4EALDH1A1GAAPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230303567-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS | ESCIENT PHARMACEUTICALS INC (US) | 2023-09-28 | — | — | US | disclosed |
| US-11667636-B2 | Modulators of Mas-related G-protein receptor X2 and related products and methods | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11667636-B2 | Modulators of Mas-related G-protein receptor X2 and related products and methods | MRGPRX2, MRGPRX1, MRGPRX4 | ADRA1D 164/4885ADRA1A 327/4885ADRA1B 254/4885 |
| US-20230303567-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND METHODS | MRGPRX2, MRGPRX1, MRGPRX4 | ADRA1D 164/4885ADRA1A 327/4885ADRA1B 254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.