Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.52 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.40 |
| ▸ | MAPT | P10636 | 8/20 | 0.40 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | USP2 | O75604 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22182585 | 1.00 | TRIM24 (0.52) | TRIM24TRIM33ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL15871031 | 0.82 | TRIM24 (0.65) | TRIM24TRIM33ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL10742280 | 0.82 | TRIM24 (0.50) | TRIM24TRIM33ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL21782323 | 0.82 | TRIM24 (0.50) | TRIM24TRIM33ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL10742284 | 0.82 | TRIM24 (0.50) | TRIM24TRIM33ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL6762457 | 0.80 | — | — | |
| SCHEMBL18270126 | 0.79 | TRIM24 (0.47) | TRIM24TRIM33ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL16770286 | 0.78 | TRIM24 (0.60) | TRIM24TRIM33ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL16770285 | 0.78 | TRIM24 (0.60) | TRIM24TRIM33ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL10178210 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170121292-A1 | HIV REPLICATION INHIBITING PYRIMIDINES | JANSSEN PHARMACEUTICA NV (BE) | 2017-05-04 | — | — | US | disclosed |
| EP-2611300-B1 | SUBSTITUTED ANNELATED DIHYDROPYRIMIDINONE COMPOUNDS | BAYER IP GMBH (DE) | 2016-04-06 | — | — | EP | disclosed |
| WO-2012028578-A1 | SUBSTITUTED FUSED PYRIMIDINONES AND DIHYDROPYRIMIDINONES | BAYER CROPSCIENCE AG (DE) | 2012-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170121292-A1 | HIV REPLICATION INHIBITING PYRIMIDINES | RRM2B, CCNO, RRM2 | TRIM24 1615/4885TRIM33 873/4885ALDH1A1 3445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.