Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 4/20 | 0.41 |
| ▸ | ACHE | P22303 | 4/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | ESRRG | P62508 | 4/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | ESRRB | O95718 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2563412 | 0.99 | HRH3 (0.41) | BCHEACHEHRH3ESRRGESR1 | |
| SCHEMBL2565894 | 0.99 | HRH3 (0.41) | BCHEACHEHRH3ESRRGESR1 | |
| SCHEMBL2563612 | 0.99 | HRH3 (0.41) | BCHEACHEHRH3ESRRGESR1 | |
| Oxalic Acid SCHEMBL5229363 | 0.94 | HRH3 (0.44) | BCHEACHEHRH3ESRRGESR1 | |
| SCHEMBL2565320 | 0.86 | HRH3 (0.43) | HRH3HRH1CHEK1ESRRGESR1 | |
| SCHEMBL2563353 | 0.84 | HRH3 (0.44) | HRH3CHEK1ESRRGESR1ESRRB | |
| SCHEMBL2565961 | 0.84 | HRH3 (0.44) | HRH3CHEK1ESRRGESR1ESRRB | |
| SCHEMBL2564698 | 0.84 | HRH3 (0.44) | HRH3CHEK1ESRRGESR1ESRRB | |
| SCHEMBL2567757 | 0.77 | PARP1 (0.41) | BCHEACHEHRH3MAOB | |
| SCHEMBL2493535 | 0.77 | PDE5A (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960387-A1 | ISOQUINOLINE ET BENZO[H]ISOQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF AS ANTAGONISTS OF HISTAMINE H3 RECEPTOR | sanofi-aventis (FR) | 2008-08-27 | — | — | EP | claimed |
| WO-2007060027-A1 | ISOQUINOLINE ET BENZO[H]ISOQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF AS ANTAGONISTS OF HISTAMINE H3 RECEPTOR | SANOFI AVENTIS (FR) | 2007-05-31 | — | — | WO | claimed |
| EP-1790646-A1 | Isoquinoline und benzo[h]isoquinoline derivatives, their preparation and their therapeutical application as antagonists of histamine H3 receptor . | Sanofi-Aventis (FR) | 2007-05-30 | — | — | EP | claimed |
| EP-1960387-B1 | ISOQUINOLINE ET BENZO[H]ISOQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF AS ANTAGONISTS OF HISTAMINE H3 RECEPTOR | SANOFI SA (FR) | 2011-11-02 | — | — | EP | disclosed |
| EP-1960387-A1 | ISOQUINOLINE ET BENZO[H]ISOQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF AS ANTAGONISTS OF HISTAMINE H3 RECEPTOR | sanofi-aventis (FR) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007060027-A1 | ISOQUINOLINE ET BENZO[H]ISOQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF AS ANTAGONISTS OF HISTAMINE H3 RECEPTOR | SANOFI AVENTIS (FR) | 2007-05-31 | — | — | WO | disclosed |
| EP-1790646-A1 | Isoquinoline und benzo[h]isoquinoline derivatives, their preparation and their therapeutical application as antagonists of histamine H3 receptor . | Sanofi-Aventis (FR) | 2007-05-30 | — | — | EP | disclosed |