Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 3/20 | 0.35 |
| ▸ | ACHE | P22303 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2563412 | 0.78 | HRH3 (0.41) | HRH3BCHEACHE | |
| SCHEMBL2565894 | 0.78 | HRH3 (0.41) | HRH3BCHEACHE | |
| SCHEMBL2563612 | 0.78 | HRH3 (0.41) | HRH3BCHEACHE | |
| SCHEMBL2560474 | 0.77 | BCHE (0.41) | HRH3MAOBBCHEACHE | |
| Oxalic Acid SCHEMBL5229363 | 0.74 | HRH3 (0.44) | HRH3BCHEACHE | |
| SCHEMBL3550839 | 0.72 | ROCK1 (0.38) | PARP1HRH3PDE4APDE4BPDE4C | |
| SCHEMBL2561968 | 0.72 | HRH3 (0.61) | HRH3CYP2D6 | |
| Oxalic Acid SCHEMBL3550835 | 0.68 | HRH3 (0.56) | HRH3CYP2D6 | |
| SCHEMBL10686530 | 0.68 | MAOA (0.46) | PARP1HRH3MAOAMAOBPDE4A | |
| SCHEMBL15881982 | 0.68 | HRH3 (0.52) | PARP1HRH3MAOAMAOBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960387-B1 | ISOQUINOLINE ET BENZO[H]ISOQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF AS ANTAGONISTS OF HISTAMINE H3 RECEPTOR | SANOFI SA (FR) | 2011-11-02 | — | — | EP | claimed |
| EP-1960387-A1 | ISOQUINOLINE ET BENZO[H]ISOQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF AS ANTAGONISTS OF HISTAMINE H3 RECEPTOR | sanofi-aventis (FR) | 2008-08-27 | — | — | EP | claimed |
| WO-2007060027-A1 | ISOQUINOLINE ET BENZO[H]ISOQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF AS ANTAGONISTS OF HISTAMINE H3 RECEPTOR | SANOFI AVENTIS (FR) | 2007-05-31 | — | — | WO | claimed |
| EP-1790646-A1 | Isoquinoline und benzo[h]isoquinoline derivatives, their preparation and their therapeutical application as antagonists of histamine H3 receptor . | Sanofi-Aventis (FR) | 2007-05-30 | — | — | EP | claimed |
| EP-1960387-B1 | ISOQUINOLINE ET BENZO[H]ISOQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF AS ANTAGONISTS OF HISTAMINE H3 RECEPTOR | SANOFI SA (FR) | 2011-11-02 | — | — | EP | disclosed |
| EP-1960387-A1 | ISOQUINOLINE ET BENZO[H]ISOQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF AS ANTAGONISTS OF HISTAMINE H3 RECEPTOR | sanofi-aventis (FR) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007060027-A1 | ISOQUINOLINE ET BENZO[H]ISOQUINOLINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF AS ANTAGONISTS OF HISTAMINE H3 RECEPTOR | SANOFI AVENTIS (FR) | 2007-05-31 | — | — | WO | disclosed |
| EP-1790646-A1 | Isoquinoline und benzo[h]isoquinoline derivatives, their preparation and their therapeutical application as antagonists of histamine H3 receptor . | Sanofi-Aventis (FR) | 2007-05-30 | — | — | EP | disclosed |