Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 2/20 | 0.35 |
| ▸ | PARG | Q86W56 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL27884093 | 0.94 | TSHR (0.37) | PDE5AALDH1A1HTR2CHTR2BTSHR | |
| Fumaric Acid SCHEMBL27884094 | 0.93 | TSHR (0.36) | PDE5AALDH1A1HTR2CHTR2BTSHR | |
| Fumaric Acid SCHEMBL27987491 | 0.93 | TSHR (0.36) | PDE5AALDH1A1HTR2CHTR2BTSHR | |
| SCHEMBL28077422 | 0.83 | CHRM3 (0.33) | PDE5AMETAP2 | |
| SCHEMBL2563612 | 0.78 | HRH3 (0.41) | — | |
| SCHEMBL2563412 | 0.78 | HRH3 (0.41) | — | |
| SCHEMBL2565894 | 0.78 | HRH3 (0.41) | — | |
| SCHEMBL1241177 | 0.78 | PNMT (0.53) | PDE5AALDH1A1HTR2CHTR2BTSHR | |
| SCHEMBL2403756 | 0.78 | PNMT (0.53) | PDE5AALDH1A1HTR2CHTR2BTSHR | |
| SCHEMBL1241268 | 0.78 | HRH3 (0.46) | ALDH1A1TSHRHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104363911-A | H3 receptor antagonist for treating Alzheimer disease | SANOFI SA | 2015-02-18 | — | — | CN | disclosed |
| CN-102803247-B | Novel fumarate salts of a histamine H3 receptor antagonist | SANOFI AVENTIS | 2014-11-05 | — | — | CN | disclosed |
| CN-103221394-A | Process for the preparation of 2-(cyclohexylmethyl)-n-{2- [(2s)-1-methylpyrrolidin-2-yl]ethyl}-1, 2, 3, 4- tetrahydroisoquinoline-7-sulfonamide | SAI NUOFEI | 2013-07-24 | — | — | CN | disclosed |
| EP-2542530-A2 | PROCESS FOR THE PREPARATION OF 2-(CYCLOHEXYLMETHYL)-N-{2- [(2S)-1-METHYLPYRROLIDIN-2-YL]ETHYL}-1, 2, 3, 4- TETRAHYDROISOQUINOLINE-7-SULFONAMIDE | SANOFI (FR) | 2013-01-09 | — | — | EP | disclosed |
| WO-2011109675-A2 | PROCESS FOR THE PREPARATION OF 2-(CYCLOHEXYLMETHYL)-N-{2- [(2S)-1-METHYLPYRROLIDIN-2-YL]ETHYL}-1, 2, 3, 4- TETRAHYDROISOQUINOLINE-7-SULFONAMIDE | SANOFI (FR) | 2011-09-09 | — | — | WO | disclosed |