SCHEMBL2560722

SCHEMBL2560722

OB(O)c1cccc(COc2ccc(F)cc2F)c1

nearest known ligand 0.47

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ENPP2 Q13822 5/20 0.47
MRGPRX4 Q96LA9 6/20 0.47
LMNA P02545 2/20 0.45
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2D6 P10635 1/20 0.44
MAPT P10636 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
MAOB P27338 3/20 0.43
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
LIPE Q05469 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2559206 0.86 ENPP2 (0.52) ENPP2MRGPRX4MEN1KMT2A
SCHEMBL15332594 0.84 ENPP2 (0.48) ENPP2MRGPRX4LMNAL3MBTL1LIPE
SCHEMBL2554083 0.84 NR3C2 (0.44) ENPP2L3MBTL1MEN1KMT2ALIPE
SCHEMBL212034 0.81 LIPE (0.53) ENPP2MRGPRX4LIPE
SCHEMBL29954345 0.81 LIPE (0.53) ENPP2MRGPRX4LIPE
SCHEMBL30719648 0.78 MRGPRX4 (0.53) MRGPRX4LMNAMAPTL3MBTL1LIPE
SCHEMBL412514 0.78 MRGPRX4 (0.53) MRGPRX4LMNAMAPTL3MBTL1LIPE
SCHEMBL2559064 0.78 ENPP2 (0.57) ENPP2MRGPRX4MAOB
SCHEMBL4304772 0.78 MAOB (0.63) ENPP2MRGPRX4MAOB
SCHEMBL13723490 0.78 ENPP2 (0.58) ENPP2MRGPRX4LMNACYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed
EP-2558577-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2013-02-20 EP disclosed
WO-2011127933-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2011-10-20 WO disclosed