SCHEMBL25608795

SCHEMBL25608795

CC(C(=O)O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)CCCCCN1C(=O)C=CC1=O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
GSK3A P49840 2/20 0.42
GSK3B P49841 2/20 0.42
PTGS1 P23219 4/20 0.41
PTGS2 P35354 4/20 0.41
MMP2 P08253 1/20 0.40
FAAH O00519 3/20 0.40
AKT1 P31749 1/20 0.40
MGLL Q99685 1/20 0.40
HPGD P15428 1/20 0.39
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
OPRM1 P35372 1/20 0.38
OPRD1 P41143 1/20 0.38
OPRK1 P41145 1/20 0.38
HDAC3 O15379 1/20 0.38
HDAC4 P56524 1/20 0.38
HDAC1 Q13547 1/20 0.38
HDAC7 Q8WUI4 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24982400 0.88 SMN1; SMN2 (0.47) ALDH1A1SMN1; SMN2GSK3AGSK3BPTGS1
SCHEMBL27379555 0.86 HPGD (0.43) ALDH1A1SMN1; SMN2GSK3AGSK3BPTGS1
SCHEMBL20787950 0.86 FAAH (0.50) ALDH1A1SMN1; SMN2GSK3AGSK3BPTGS1
SCHEMBL17003656 0.86 FAAH (0.50) ALDH1A1SMN1; SMN2GSK3AGSK3BPTGS1
SCHEMBL29235949 0.85 FAAH (0.51) ALDH1A1SMN1; SMN2GSK3AGSK3BPTGS1
SCHEMBL29114311 0.85 FAAH (0.51) ALDH1A1SMN1; SMN2GSK3AGSK3BPTGS1
SCHEMBL25748819 0.83 AKT1 (0.48) ALDH1A1SMN1; SMN2AKT1HPGDOPRM1
SCHEMBL28931814 0.82 ALDH1A1 (0.46) ALDH1A1SMN1; SMN2GSK3AGSK3BPTGS1
SCHEMBL25967838 0.82 AKT1 (0.50) ALDH1A1SMN1; SMN2FAAHAKT1HDAC3
SCHEMBL25975485 0.82 AKT1 (0.50) ALDH1A1SMN1; SMN2FAAHAKT1HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023088382-A1 ANTIBODY-DRUG CONJUGATE AND USE THEREOF 石药集团巨石生物制药有限公司 2023-05-25 WO disclosed