SCHEMBL2560988

SCHEMBL2560988

NC1CC1c1ccc(NC(=O)c2ccc(-c3ccccc3)cc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 17/20 1.00
MAOA P21397 14/20 0.84
MAOB P27338 12/20 0.84
RCOR1 Q9UKL0 7/20 0.84
KDM1B Q8NB78 4/20 0.84
PTPN1 P18031 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17287978 1.00 KDM1A (1.00) KDM1AMAOAMAOBRCOR1KDM1B
Hydrochloric Acid SCHEMBL15789049 0.99 KDM1A (0.97) KDM1AMAOAMAOBRCOR1KDM1B
Hydrochloric Acid SCHEMBL15789047 0.99 KDM1A (0.97) KDM1AMAOAMAOBRCOR1KDM1B
SCHEMBL17003580 0.91 MAOA (1.00) KDM1AMAOAMAOBRCOR1KDM1B
SCHEMBL15944933 0.91 KDM1A (1.00) KDM1AMAOAMAOBRCOR1KDM1B
SCHEMBL21471753 0.91 KDM1A (1.00) KDM1AMAOAMAOBRCOR1KDM1B
SCHEMBL12813993 0.91 KDM1A (1.00) KDM1AMAOAMAOBRCOR1KDM1B
SCHEMBL2557921 0.91 KDM1A (1.00) KDM1AMAOAMAOBRCOR1KDM1B
SCHEMBL17003579 0.91 MAOA (1.00) KDM1AMAOAMAOBRCOR1KDM1B
Hydrochloric Acid SCHEMBL15789125 0.90 KDM1A (1.00) KDM1AMAOAMAOBRCOR1KDM1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3224352-B1 REPROGRAMMING-BASED MODELS OF NEURODEVELOPMENTAL DISORDERS AND USES THEREOF ST EUROPEO DI ONCOLOGIA S R L (IT) 2024-01-03 EP claimed
EP-2560949-B1 TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASE LSD1 AND/OR LSD2 UNIVERSIT DEGLI STUDI DI ROMA LA SAPIENZA (IT) 2015-12-02 EP claimed
US-8765820-B2 Tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and/or LSD2 Universita Degli Studi Di Roma “La Sapienza” (IT) 2014-07-01 US claimed
EP-2560949-A1 TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASE LSD1 AND/OR LSD2 Università degli Studi di Roma "La Sapienza" (IT) 2013-02-27 EP claimed
US-20130035377-A1 TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASES LSD1 AND/OR LSD2 UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (IT) 2013-02-07 US claimed
WO-2011131576-A1 TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASE LSD1 AND/OR LSD2 UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (IT) 2011-10-27 WO claimed
US-11918580-B2 Use of a combinational therapy of LSD1 inhibitors with P21 activators in the treatment of cancer ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) 2024-03-05 US disclosed
US-20210100800-A1 USE OF A COMBINATIONAL THERAPY OF LSD1 INHIBITORS WITH P21 ACTIVATORS IN THE TREATMENT OF CANCER INSTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) 2021-04-08 US disclosed
US-10233165-B2 Cyclopropylamine compounds as histone demethylase inhibitors ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) 2019-03-19 US disclosed
US-20180311245-A1 USE OF A COMBINATIONAL THERAPY OF LSD1 INHIBITORS WITH CDK2 INHIBITORS IN THE TREATMENT OF CANCER RASNA THERAPEUTICS LTD (GB) 2018-11-01 US disclosed
WO-2018197583-A1 USE OF A COMBINATIONAL THERAPY OF LSD1 INHIBITORS WITH P21 ACTIVATORS IN THE TREATMENT OF CANCER ISTITUTO EUROPEO DI ONCOLOGIA (IT) 2018-11-01 WO disclosed
EP-3148974-B1 CYCLOPROPYLAMINE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS ST EUROPEO DI ONCOLOGIA S R L (IT) 2018-09-26 EP disclosed
WO-2017097865-A9 COMBINATION OF CALORIC RESTRICTION (CR) OR IGF1/INSULIN RECEPTOR INHIBITOR WITH LSD1 INHIBITOR ISTITUTO EUROPEO DI ONCOLOGIA (IT) 2017-08-31 WO disclosed
US-20170190680-A1 CYCLOPROPYLAMINE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS IEO - ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) 2017-07-06 US disclosed
WO-2017097865-A1 COMBINATION OF CALORIC RESTRICTION (CR) OR IGF1/INSULIN RECEPTOR INHIBITOR WITH LSD1 INHIBITOR ISTITUTO EUROPEO DI ONCOLOGIA (IT) 2017-06-15 WO disclosed
CN-103842332-B Cyclopropylamine compound 武田药品工业株式会社 2016-08-17 CN disclosed
EP-2560949-B1 TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASE LSD1 AND/OR LSD2 UNIVERSIT DEGLI STUDI DI ROMA LA SAPIENZA (IT) 2015-12-02 EP disclosed
US-8765820-B2 Tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and/or LSD2 Universita Degli Studi Di Roma “La Sapienza” (IT) 2014-07-01 US disclosed
US-20130035377-A1 TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASES LSD1 AND/OR LSD2 UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA" (IT) 2013-02-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180311245-A1 USE OF A COMBINATIONAL THERAPY OF LSD1 INHIBITORS WITH CDK2 INHIBITORS IN THE TREATMENT OF CANCER CDK2, EZH2, CDK6 KDM1A 16/4885MAOA 1955/4885MAOB 1751/4885
US-20210100800-A1 USE OF A COMBINATIONAL THERAPY OF LSD1 INHIBITORS WITH P21 ACTIVATORS IN THE TREATMENT OF CANCER CDK6, KDM1B, KDM6B KDM1A 7/4885MAOA 1440/4885MAOB 1514/4885
US-20130035377-A1 TRANYLCYPROMINE DERIVATIVES AS INHIBITORS OF HISTONE DEMETHYLASES LSD1 AND/OR LSD2 KDM1B, KDM2A, KDM3A KDM1A 4/4885MAOA 103/4885MAOB 72/4885
US-11918580-B2 Use of a combinational therapy of LSD1 inhibitors with P21 activators in the treatment of cancer CDK6, KDM1B, KDM6B KDM1A 7/4885MAOA 1440/4885MAOB 1514/4885
US-10233165-B2 Cyclopropylamine compounds as histone demethylase inhibitors KDM1B, PHF2, KDM6B KDM1A 12/4885MAOA 439/4885MAOB 425/4885
US-20170190680-A1 CYCLOPROPYLAMINE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS KDM1B, PHF2, KDM6B KDM1A 12/4885MAOA 439/4885MAOB 425/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.