⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10665033 | 0.72 | — | — | |
| SCHEMBL5724937 | 0.71 | — | — | |
| SCHEMBL23004381 | 0.67 | OPRM1 (0.39) | — | |
| SCHEMBL1717722 | 0.67 | DNM1 (0.38) | — | |
| SCHEMBL16837368 | 0.67 | — | — | |
| SCHEMBL13375766 | 0.67 | — | — | |
| SCHEMBL4250670 | 0.67 | — | — | |
| SCHEMBL17746589 | 0.67 | TSHR (0.33) | — | |
| Butane SCHEMBL28456059 | 0.67 | — | — | |
| Butane SCHEMBL31240952 | 0.67 | TSHR (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4077303-A1 | SUBSTITUTED THIOPHENE CARBOXAMIDES AND DERIVATIVES THEREOF AS MICROBICIDES | Bayer Aktiengesellschaft (DE) | 2022-10-26 | — | — | EP | disclosed |
| EP-4041399-A1 | HETEROCYCLIC DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND THEIR USE IN THE TREATMENT OR AMELIORATION OF CANCER | Tolremo Therapeutics AG (CH) | 2022-08-17 | — | — | EP | disclosed |
| EP-2984092-A1 | SPIROINDOLINE DERIVATIVES FOR USE AS GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS | Bayer Pharma Aktiengesellschaft (DE) | 2016-02-17 | — | — | EP | disclosed |
| WO-2015007606-A1 | SPIROINDOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-01-22 | — | — | WO | disclosed |
| WO-2014166958-A1 | SPIROINDOLINE DERIVATIVES FOR USE AS GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2014-10-16 | — | — | WO | disclosed |
| EP-2560958-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | Syngenta Participations AG (CH) | 2013-02-27 | — | — | EP | disclosed |
| EP-2560960-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | Syngenta Participations AG (CH) | 2013-02-27 | — | — | EP | disclosed |
| EP-2560959-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | Syngenta Participations AG (CH) | 2013-02-27 | — | — | EP | disclosed |
| WO-2011131546-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-10-27 | — | — | WO | disclosed |
| WO-2011131545-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-10-27 | — | — | WO | disclosed |
| WO-2011131544-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-10-27 | — | — | WO | disclosed |