Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 3/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.44 |
| ▸ | WNT1 | P04628 | 1/20 | 0.44 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 5/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25610594 | 0.83 | MKNK1 (0.55) | MKNK1GSK3BDYRK1AWNT1UCHL1 | |
| SCHEMBL25612174 | 0.80 | MKNK1 (0.54) | MKNK1GSK3BDYRK1AWNT1UCHL1 | |
| SCHEMBL25611610 | 0.79 | MKNK1 (0.55) | MKNK1GSK3BDYRK1AWNT1UCHL1 | |
| SCHEMBL25605337 | 0.77 | MKNK1 (0.64) | MKNK1GSK3BDYRK1AWNT1UCHL1 | |
| SCHEMBL30481263 | 0.77 | CSNK2A2 (0.41) | — | |
| SCHEMBL31272043 | 0.76 | MKNK1 (0.66) | MKNK1GSK3BDYRK1AWNT1UCHL1 | |
| SCHEMBL25605166 | 0.76 | MKNK1 (0.58) | MKNK1GSK3BDYRK1AWNT1UCHL1 | |
| SCHEMBL25605170 | 0.75 | MKNK1 (0.74) | MKNK1GSK3BDYRK1AWNT1UCHL1 | |
| SCHEMBL25610896 | 0.75 | MKNK1 (0.61) | MKNK1GSK3BDYRK1AWNT1UCHL1 | |
| SCHEMBL25612824 | 0.75 | MAPT (0.42) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023107714-A2 | METHODS FOR TREATING NEUROLOGICAL DISORDERS | PROTHENA BIOSCIENCES LIMITED (IE) | 2023-06-15 | — | — | WO | disclosed |