Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.41 |
| ▸ | BRD4 | O60885 | 5/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TAF1 | P21675 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | POLQ | O75417 | 1/20 | 0.33 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.33 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25420455 | 1.00 | CSNK2A2 (0.41) | CSNK2A2CSNK2A1BRD4PDE10AKDM4E | |
| SCHEMBL25612824 | 0.81 | MAPT (0.42) | CSNK2A2CSNK2A1PDE10AKDM4EMEN1 | |
| SCHEMBL25612327 | 0.77 | MKNK1 (0.54) | — | |
| SCHEMBL25605965 | 0.75 | XDH (0.42) | CSNK2A2CSNK2A1PDE10AKDR | |
| SCHEMBL25613674 | 0.66 | PDE10A (0.43) | CSNK2A2CSNK2A1PDE10AKDM4EMEN1 | |
| SCHEMBL25605163 | 0.66 | PDE10A (0.49) | CSNK2A2CSNK2A1PDE10AKDM4EMEN1 | |
| SCHEMBL25421541 | 0.66 | XDH (0.41) | CSNK2A2CSNK2A1PDE10AKDR | |
| SCHEMBL25610594 | 0.65 | MKNK1 (0.55) | RAB9A | |
| SCHEMBL25418143 | 0.63 | XDH (0.42) | CSNK2A2CSNK2A1PDE10AKDRSTIM1 | |
| SCHEMBL31501375 | 0.63 | CSNK2A2 (0.50) | CSNK2A2CSNK2A1PDE10AKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118843626-A | Heterocyclic compounds as DYRK1A inhibitors | 普罗塞纳生物科学有限公司 | 2024-10-25 | — | — | CN | disclosed |
| EP-4444421-A2 | HETEROCYCLIC COMPOUNDS AS DYRK1A INHIBITORS | Prothena Biosciences Limited (IE) | 2024-10-16 | — | — | EP | disclosed |
| WO-2023107714-A2 | METHODS FOR TREATING NEUROLOGICAL DISORDERS | PROTHENA BIOSCIENCES LIMITED (IE) | 2023-06-15 | — | — | WO | disclosed |