Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.49 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 9/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | ROS1 | P08922 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | MARK3 | P27448 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25613153 | 0.87 | HRH4 (0.41) | PIK3CAPIK3R1JAK3LRRK2ROCK1 | |
| SCHEMBL25626100 | 0.82 | PIK3CA (0.52) | PIK3CAPIK3R1JAK3MTORPIK3CG | |
| SCHEMBL25613160 | 0.78 | ALOX15 (0.41) | PIK3CAPIK3R1MTORLMNAPLK4 | |
| SCHEMBL25613068 | 0.73 | CYP3A4 (0.45) | POLBLMNAKDM4E | |
| SCHEMBL18557385 | 0.73 | PIK3CA (0.67) | PIK3CAPIK3R1JAK3MTORPIK3CD | |
| SCHEMBL25613029 | 0.71 | FEN1 (0.39) | PIK3CAPIK3CGPIK3CDLRRK2PLK4 | |
| SCHEMBL16835984 | 0.70 | PIK3CA (0.48) | PIK3CAPIK3R1JAK3MTORPOLB | |
| SCHEMBL13604904 | 0.70 | CDK8 (0.39) | PIK3CAPIK3CGPIK3CDLRRK2PLK4 | |
| SCHEMBL5413458 | 0.69 | PIK3CA (0.50) | PIK3CAPIK3R1JAK3MTORPIK3CG | |
| SCHEMBL856151 | 0.69 | PIK3CA (0.51) | PIK3CAPIK3R1JAK3MTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159527-A1 | COMPOUNDS AS BCL-2 INHIBITORS | FOCHON BIOSCIENCES, LTD. (CN) | 2023-05-25 | — | — | US | disclosed |
| US-20230159527-A1 | COMPOUNDS AS BCL-2 INHIBITORS | FOCHON BIOSCIENCES, LTD. (CN) | 2023-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159527-A1 | COMPOUNDS AS BCL-2 INHIBITORS | BCL2, BCL2L2, BCL2L1 | PIK3CA 1141/4885PIK3R1 254/4885JAK3 3456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.