Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 8/20 | 0.37 |
| ▸ | HTR2A | P28223 | 4/20 | 0.37 |
| ▸ | HTR2B | P41595 | 3/20 | 0.37 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.35 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.35 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.35 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.35 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.35 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.35 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.35 |
| ▸ | CACNG1 | Q06432 | 1/20 | 0.35 |
| ▸ | CACNB2 | Q08289 | 1/20 | 0.35 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11738033 | 0.75 | CHRNB2 (0.46) | HTR2CHTR2AHTR2BHTR1ARECQL | |
| SCHEMBL4404195 | 0.75 | CHRNB2 (0.46) | HTR2CHTR2B | |
| SCHEMBL4689201 | 0.75 | — | — | |
| SCHEMBL853286 | 0.71 | CHRNB4 (0.40) | HTR2AMEN1KMT2A | |
| SCHEMBL4402527 | 0.71 | MEN1 (0.38) | CYP2A6MEN1KMT2A | |
| Water SCHEMBL7405955 | 0.69 | CACNB4 (0.39) | SMN1; SMN2HTR2CHTR2AHTR2BCACNB4 | |
| Bromide SCHEMBL8344294 | 0.69 | CACNB4 (0.39) | SMN1; SMN2HTR2CHTR2AHTR2BCACNB4 | |
| SCHEMBL14825017 | 0.67 | ACHE (0.45) | SMN1; SMN2HTR2CHTR2AHTR2BCACNB4 | |
| SCHEMBL14682288 | 0.65 | HTR2C (0.40) | SMN1; SMN2HTR2CHTR2AHTR2BCACNB4 | |
| SCHEMBL11533051 | 0.65 | CHRNB2 (0.47) | HTR2CHTR2AHTR2BCACNB4CACNA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560959-B1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2014-08-20 | — | — | EP | disclosed |
| EP-2560959-B1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2014-08-20 | — | — | EP | disclosed |
| US-8519152-B2 | Process for the preparation of pyrazole carboxylic acid amides | SYNGENTA CROP PROTECTION LLC (US) | 2013-08-27 | — | — | US | disclosed |
| US-8519152-B2 | Process for the preparation of pyrazole carboxylic acid amides | SYNGENTA CROP PROTECTION LLC (US) | 2013-08-27 | — | — | US | disclosed |
| US-8519152-B2 | Process for the preparation of pyrazole carboxylic acid amides | SYNGENTA CROP PROTECTION LLC (US) | 2013-08-27 | — | — | US | disclosed |
| EP-2560959-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | Syngenta Participations AG (CH) | 2013-02-27 | — | — | EP | disclosed |
| US-20130035496-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | SYNGENTA CROP PROTECTION LLC (US) | 2013-02-07 | — | — | US | disclosed |
| US-20130035496-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | SYNGENTA CROP PROTECTION LLC (US) | 2013-02-07 | — | — | US | disclosed |
| US-20130035496-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | SYNGENTA CROP PROTECTION LLC (US) | 2013-02-07 | — | — | US | disclosed |
| WO-2011131545-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-10-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130035496-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES | F5, F12, F9 | SMN1; SMN2 4782/4885HTR2C 3918/4885HTR2A 4378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.