Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.51 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.51 |
| ▸ | TTK | P33981 | 2/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.48 |
| ▸ | PI4KA | P42356 | 1/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.48 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 10/20 | 0.47 |
| ▸ | GSK3B | P49841 | 9/20 | 0.47 |
| ▸ | WNT1 | P04628 | 5/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 2/20 | 0.46 |
| ▸ | CLK3 | P49761 | 2/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
| ▸ | JUN | P05412 | 2/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20951302 | 0.84 | PIK3CD (0.53) | MAP4K3MAP4K1TTKPIK3CDPIK3CA | |
| SCHEMBL25613558 | 0.81 | MAP4K1 (0.52) | MAP4K3MAP4K1TTKPIK3CDPIK3CA | |
| SCHEMBL20948560 | 0.79 | DYRK1A (0.62) | MAP4K3MAP4K1DYRK1AGSK3BWNT1 | |
| SCHEMBL31071772 | 0.79 | PIK3CD (0.48) | MAP4K3MAP4K1TTKPIK3CDPIK3CA | |
| SCHEMBL31522654 | 0.77 | PIK3CD (0.56) | MAP4K3MAP4K1TTKPIK3CDPIK3CA | |
| SCHEMBL25613555 | 0.77 | TTK (0.42) | MAP4K1TTK | |
| SCHEMBL27391685 | 0.76 | PIK3CD (0.48) | TTKPIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL13355086 | 0.76 | MET (0.62) | PIK3CDPIK3CAPIK3CBPI4KAPIK3CG | |
| SCHEMBL25646429 | 0.74 | GSK3B (0.57) | DYRK1AGSK3BWNT1ABL1CLK2 | |
| SCHEMBL25419916 | 0.74 | LRRK2 (0.52) | PIK3CDPIK3CAPIK3CBPI4KAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023107722-A1 | COMPOUNDS FOR USE IN TREATING NEUROLOGICAL DISORDERS | PROTHENA BIOSCIENCES LIMITED (IE) | 2023-06-15 | — | — | WO | disclosed |
| WO-2023107714-A2 | METHODS FOR TREATING NEUROLOGICAL DISORDERS | PROTHENA BIOSCIENCES LIMITED (IE) | 2023-06-15 | — | — | WO | disclosed |