Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 10/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 10/20 | 0.50 |
| ▸ | CNR2 | P34972 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | WNT1 | P04628 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25613753 | 0.85 | GSK3B (0.40) | GSK3BDYRK1ACNR2LMNAWNT1 | |
| SCHEMBL31271677 | 0.83 | GSK3B (0.52) | GSK3BDYRK1ACNR2WNT1SMN1; SMN2 | |
| SCHEMBL25613237 | 0.83 | GSK3B (0.52) | GSK3BDYRK1ACNR2WNT1SMN1; SMN2 | |
| SCHEMBL20949480 | 0.82 | GSK3B (0.55) | GSK3BDYRK1ALMNAWNT1NPC1 | |
| SCHEMBL25614117 | 0.82 | WNT1 (0.49) | GSK3BDYRK1ACNR2WNT1SMN1; SMN2 | |
| SCHEMBL25613750 | 0.81 | GSK3B (0.53) | GSK3BDYRK1ACNR2LMNAWNT1 | |
| SCHEMBL25613669 | 0.79 | ABL1 (0.46) | GSK3BDYRK1AWNT1NPC1SMN1; SMN2 | |
| SCHEMBL25612756 | 0.78 | DYRK1A (0.66) | GSK3BDYRK1AWNT1ABL1 | |
| SCHEMBL25613678 | 0.77 | GSK3B (0.54) | GSK3BDYRK1AWNT1RAB9AABL1 | |
| SCHEMBL25613668 | 0.77 | GSK3B (0.43) | GSK3BDYRK1ACNR2WNT1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023107714-A2 | METHODS FOR TREATING NEUROLOGICAL DISORDERS | PROTHENA BIOSCIENCES LIMITED (IE) | 2023-06-15 | — | — | WO | disclosed |