SCHEMBL2561431

SCHEMBL2561431

Cc1cc(F)c2[nH]c(-c3cc(F)ccc3F)c(C=O)c2c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
APOL1 O14791 4/20 0.36
ALDH1A1 P00352 3/20 0.34
MEN1 O00255 1/20 0.34
THRB P10828 1/20 0.34
HPGD P15428 1/20 0.34
KMT2A Q03164 1/20 0.34
NPY5R Q15761 1/20 0.32
SLC9A1 P19634 1/20 0.32
KDM4E B2RXH2 1/20 0.31
KIF11 P52732 2/20 0.31
NISCH Q9Y2I1 1/20 0.31
PARP1 P09874 1/20 0.30
KIT P10721 1/20 0.30
CCNB2 O95067 1/20 0.30
CDK1 P06493 1/20 0.30
CCNB1 P14635 1/20 0.30
CCNA2 P20248 1/20 0.30
CDK2 P24941 1/20 0.30
CCNA1 P78396 1/20 0.30
CDK5 Q00535 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15332296 0.91 MAPT (0.37) ALDH1A1MEN1THRBHPGDKMT2A
SCHEMBL2558629 0.90 ALDH1A1 (0.42) APOL1ALDH1A1MEN1THRBHPGD
SCHEMBL2579477 0.88 APOL1 (0.39) APOL1
SCHEMBL15331396 0.85 TNKS (0.39) APOL1ALDH1A1CDK1CDK2CDK5
SCHEMBL15332815 0.84 APOL1 (0.46) APOL1ALDH1A1
SCHEMBL15332781 0.83 TNKS (0.36) APOL1ALDH1A1MEN1KMT2AKDM4E
SCHEMBL15330593 0.82 ALDH1A1 (0.48) ALDH1A1MEN1THRBHPGDKMT2A
SCHEMBL15330688 0.81 CNR1 (0.39) ALDH1A1PARP1HTT
SCHEMBL2562716 0.81 APOL1 (0.39) APOL1ALDH1A1
SCHEMBL2562653 0.81 MEN1 (0.41) ALDH1A1MEN1THRBHPGDKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed
EP-2558577-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2013-02-20 EP disclosed
WO-2011127933-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2011-10-20 WO disclosed